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- W2481188017 endingPage "403" @default.
- W2481188017 startingPage "323" @default.
- W2481188017 abstract "This chapter illustrates DNA structure and properties and classes of drugs that interact with DNA. DNA is composed of four deoxyribonucleotides, containing two purine bases called adenine (A) and guanine (G) and two pyrimidine bases called cytosine (C) and thymine (T), which are linked by bonds joining the 5'-phosphate group of one nucleotide to a 3'-hydroxyl group on the sugar of the adjacent nucleotide to form 3' 5'-phosphodiester linkages. The chapter also illustrates DNA-interactive drugs that are toxic to normal cells. These drugs are reserved only for life-threatening diseases. It describes the organic chemistry of DNA-interactive drugs and the ways in which DNA damage relates to cancer chemotherapy. There are three major classes of clinically important DNA-interactive drugs: reversible binders, which interact with DNA through the reversible formation of noncovalent interactions; alkylators, which react covalently with DNA bases; and DNA strand breakers, which generate reactive radicals that produce cleavage of the polynucleotide strands. Research have been carried out to determine cleavage site preferences in the minor groove for each of the strand breakers. The preferences are rationalized as occurring because of the selective binding at particular sites based on the structure of the compound." @default.
- W2481188017 created "2016-08-23" @default.
- W2481188017 creator A5036064752 @default.
- W2481188017 date "2004-01-01" @default.
- W2481188017 modified "2023-09-26" @default.
- W2481188017 title "DNA-Interactive Agents" @default.
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