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- W2481207659 endingPage "385" @default.
- W2481207659 startingPage "335" @default.
- W2481207659 abstract "Enteric bacterial pathogens may be divided into two pathovars: The noninvasive pathovar, exemplified by Vibrio cholerae and enterotoxigenic Escherichia coli (ETEC), cause disease by adhering to the apical side of the small intestinal epithelium and by secreting enterotoxins, thereby causing massive water and electrolyte secretion. Likewise, enteropathogenic E. coli (EPEC) and enterohemorrhagic E. coli (EHEC) colonize and partially destroy the epithelium. EHEC may even cause bloody diarrhea due to the production of Shiga-like toxins. However, in spite of significant epithelial alterations, these bacteria are not significantly invasive and the syndrome they cause is still dominated by watery diarrhea. In the case of Salmonella typhi infection, the intestinal phase of the invasive process may lead to limited symptoms, but crossing of the epithelial barrier allows the microorganisms to enter a septicemic phase that causes the systemic symptoms and complications characteristic of typhoid fever. In the case of Shigella , the invasive process remains localized to the colonic and rectal mucosa, thereby causing major inflammatory destruction that accounts for a dysenteric syndrome, thus the name bacillary dysentery. In many cases, however, shigellosis causes only a watery diarrhea similar to that observed with noninvasive pathogens." @default.
- W2481207659 created "2016-08-23" @default.
- W2481207659 creator A5032887436 @default.
- W2481207659 creator A5065215558 @default.
- W2481207659 creator A5069666784 @default.
- W2481207659 date "2001-01-01" @default.
- W2481207659 modified "2023-09-27" @default.
- W2481207659 title "Shigellosis: From Disease Symptoms to Molecular and Cellular Pathogenesis" @default.
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