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• W2481347953 abstract "Anthracyline antibiotics make up an important class of antitumour/ anticancer compounds. Among them daunorubicin and doxorubicin (Figure 2.1), currently in widespread clinical use, are prominent members (Lown, 1988; Denny, 1989; Pullman and Jortner, 1990). The chemical structure of anthracycline antibiotics includes an aglycone chromophore with one or more sugar moieties attached. It has been shown that the biological activities of daunorubicin and doxorubicin are likely to be associated with their DNA binding properties. While these two drugs have proven to be quite effective, they none the less have some shortcomings, most notably their significant cardiotoxicity and the drug resistance that develops in some cancer cells. These problems have prompted the search for new drugs that do not have those undesirable properties. An emerging useful approach is to rationally design new compounds on the basis of the structure—function relationships of the existing drugs." @default.
• W2481347953 created "2016-08-23" @default.
• W2481347953 creator A5016567722 @default.
• W2481347953 date "1993-01-01" @default.
• W2481347953 modified "2023-10-16" @default.
• W2481347953 title "Structure-Activity Studies of Anthracycline-DNA Complexes" @default.
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• W2481347953 doi "https://doi.org/10.1007/978-1-349-12356-8_2" @default.
• W2481347953 hasPublicationYear "1993" @default.
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