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- W2481523718 abstract "A water-soluble polymeric drug containing 26% of methotrexate-γ-hydrazide (MTX-hy) was synthesized by covalently coupling of MTX-hy to divinyl ether-maleic anhydride (MVE). The advantage of the polymeric drug (MVE-hy-MTX) is that drug attachment was not through the amino groups of the pteridine ring or the alpha-carboxyl group of the glutamic acid moiety, but rather through the amino group of the gamma-hydrazide of the glutamic acid moiety. MVE-hy- MTX was more active than MTX-hy against P388 leukemia in mice. Treatment with MVE-hy-MTX against human myeloid HL60 leukemia in athymic mice showed 96% tumor growth inhibition with no deaths at day 28 post treatment, while at the same dosage, MTX-hy produced 41% tumor inhibition with 83% survival. MVE-hy-MTX was equally active and approximately 8 to 10-fold less potent compared to free methotrexate in these studies." @default.
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- W2481523718 date "1991-08-15" @default.
- W2481523718 modified "2023-09-23" @default.
- W2481523718 title "Methotrexate-γ-Hydrazide and Divinyl Ether—Maleic Anhydride Conjugate" @default.
- W2481523718 doi "https://doi.org/10.1021/bk-1991-0469.ch009" @default.
- W2481523718 hasPublicationYear "1991" @default.
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