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• W2481594651 abstract "Abstract Protein function and dynamics are closely related to its sequence and structure.However, prediction of protein function and dynamics from its sequence and structure is still a fundamental challenge in molecular biology. Protein classification, which is typically done through measuring the similarity between proteins based on protein sequence or physical information, serves as a crucial step toward the understanding of protein function and dynamics. Persistent homology is a new branch of algebraic topology that has found its success in the topological data analysis in a variety of disciplines, including molecular biology. The present work explores the potential of using persistent homology as an independent tool for protein classification. To this end, we propose a molecular topological fingerprint based support vector machine (MTF-SVM) classifier. Specifically,we construct machine learning feature vectors solely fromprotein topological fingerprints,which are topological invariants generated during the filtration process. To validate the presentMTF-SVMapproach, we consider four types of problems. First, we study protein-drug binding by using the M2 channel protein of influenza A virus. We achieve 96% accuracy in discriminating drug bound and unbound M2 channels. Secondly, we examine the use of MTF-SVM for the classification of hemoglobin molecules in their relaxed and taut forms and obtain about 80% accuracy. Thirdly, the identification of all alpha, all beta, and alpha-beta protein domains is carried out using 900 proteins.We have found a 85% success in this identification. Finally, we apply the present technique to 55 classification tasks of protein superfamilies over 1357 samples and 246 tasks over 11944 samples. Average accuracies of 82% and 73% are attained. The present study establishes computational topology as an independent and effective alternative for protein classification." @default.
• W2481594651 created "2016-08-23" @default.
• W2481594651 creator A5021484581 @default.
• W2481594651 creator A5038778212 @default.
• W2481594651 creator A5060319992 @default.
• W2481594651 creator A5068318756 @default.
• W2481594651 creator A5084610901 @default.
• W2481594651 creator A5091214287 @default.
• W2481594651 date "2015-11-30" @default.
• W2481594651 modified "2023-10-12" @default.
• W2481594651 title "A topological approach for protein classification" @default.
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