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- W2481736789 abstract "Aim . To investigate the effect of Tongxinluo (Txl), a Chinese herbal compound, on diabetic peripheral neuropathy (DPN). Methods and Results . Diabetic rat model was established by peritoneal injection of streptozotocin (STZ). Txl ultrafine powder treatment for 16 weeks from the baseline significantly reversed the impairment of motor nerve conductive velocity (MNCV), mechanical hyperalgesia, and nerve structure. We further proved that Tongxinluo upregulates PGC-1 α and its downstream factors including COX IV and SOD, which were involved in mitochondrial biogenesis. Conclusion. Our study indicates that the protective effect of Txl in diabetic neuropathy may be attributed to the induction of PGC-1 α and its downstream targets. This finding may further illustrate the pleiotropic effect of the medicine." @default.
- W2481736789 created "2016-08-23" @default.
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- W2481736789 date "2016-01-01" @default.
- W2481736789 modified "2023-10-12" @default.
- W2481736789 title "PGC-1αMediated Peripheral Nerve Protection of Tongxinluo in STZ-Induced Diabetic Rats" @default.
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- W2481736789 doi "https://doi.org/10.1155/2016/1287909" @default.
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