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• W2481766851 abstract "Abstract Background Co‐stimulatory receptor ( COR ) and ligand ( COL ) expression on immune effectors are known to be relevant for immunological interactions and might be of prognostic relevance if expressed on acute myeloid leukemia ( AML ) blasts as reported for receptors of the tumor necrosis factor receptor family. Aim and methods Antigen expression profiling of COR ( RANK , PD ‐1), COL ( RANK ‐L, PD ‐1L), and HLA ‐ ABC ‐antigens on blasts from 90 AML ‐patients at first diagnosis was performed by flow cytometry ( SFI ‐Level characterization) and findings were correlated with clinical parameters. Results RANK expression was higher in immature compared to mature FAB groups ( P = 0.08). As a monocytic marker, we identified HLA ‐ ABC ( P = 0.07). Prognostic analysis revealed a higher probability of overall survival in cases with lower RANK ‐L expression (<1.6 and ≥1.6, 15.6 vs. 12.2 months, P = 0.008, hazard ratio 0.36, P = 0.008). No significant impact of PD ‐1/L expression for patients’(pts) survival was seen but a correlation of PD ‐1 with a secondary AML ( P = 0.03). Prolonged disease‐free survival however correlated with higher PD ‐1 expression (≥1.1 vs. <1.1, 31.4 vs. 12.7 months; P = 0.03). Conclusion Our study revealed that RANK ‐L is a promising marker to forecast pts’ prognosis in AML . Immune checkpoint receptor PD ‐1/L as well as RANK and HLA ‐ ABC did not show an impact on pts’ survival." @default.
• W2481766851 created "2016-08-23" @default.
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• W2481766851 date "2016-06-05" @default.
• W2481766851 modified "2023-10-04" @default.
• W2481766851 title "Expression of RANK-L and in part of PD-1 on blasts in patients with acute myeloid leukemia correlates with prognosis" @default.
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• W2481766851 doi "https://doi.org/10.1111/ejh.12762" @default.
• W2481766851 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27096305" @default.
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