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- W2481838862 abstract "In order to provide a macromolecular prodrug of 5-fluorouracil(5FU) with reduced side-effects, having affinity for tumor cells and exhibiting a high antitumor activity, the design of polysaccharide-5FU conjugates was investigated. Chitin-5FU, chitosan-5FU, α-1,4-polygalactosamine-5FU, partially N-acetylated α-1,4-polygalactosamine-5FU, hyaluronic acid-5FU and dextran-5FU conjugates exhibited significant survival effects against p388 lymphocytic leukemia in mice by intraperitoneal(ip) transplantation/intraperitoneal(ip) injection. Chitosan-5FU, chitosamino-oligosaccharide-5FU, and galactosamino-oligosaccharide-5FU conjugates showed higher growth-inhibitory effects against MH134Y hepatoma and Meth-A fibrosarcoma in mice than 5FU, chitin, oligosaccharides and their blends by subcutaneous(sc) implantation/intravenous(iv) injection. The obtained conjugates did not display an acute toxicity in the high dose ranges." @default.
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- W2481838862 date "1991-08-15" @default.
- W2481838862 modified "2023-09-25" @default.
- W2481838862 title "Design of Polysaccharide-5-Fluorouracil Conjugates Exhibiting Antitumor Activities" @default.
- W2481838862 doi "https://doi.org/10.1021/bk-1991-0469.ch008" @default.
- W2481838862 hasPublicationYear "1991" @default.
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