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- W2481929703 abstract "Evidence can help in several ways. For instance, knowing the relative efficacy of interventions for acute pain 1,2 demonstrates that some interventions are clearly better than others. Oral NSAIDs at standard doses, and combinations like paracetamol 1000 mg plus codeine 60 mg, do particularly well. A problem is that adverse event information is not well collected, nor is it presented in standard format, 3 so that we do not have equivalent relative harm to go with relative efficacy. The cost of individual interventions can be widely different between countries, and availability is a particular issue in many parts of the world, either because of supply or regulation. For these and other reasons (like the unique biology of the patient) we always hesitate before recommending any particular treatment, because evidence can be used only as a tool to aid our own judgment, not a rule to enforce judgments of others. Combination analgesics can be effective and provide more analgesia than either alone, as with paracetamol and codeine. 4,5 The difficulty is demonstrating it, because single small trials will not have the power to do so. 6 Our experience is that this is an agenda driven more by patents than science. NB: The quotation “The combination is good but ibuprofen is better” is not from our paper, but may mislead readers into thinking that it is." @default.
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- W2481929703 date "2002-01-01" @default.
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- W2481929703 title "Audio-Visual Communication and Its Use in Palliative Care" @default.
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