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- W2482027424 abstract "Selective visualization of arginine and lysine has been explored among 20 amino acids using the hybrid conjugate of β-cyclodextrin (β-CD) and polydiacetylene (PDA). The mono pentacosa-10,12-diynyl aminomethyl group was successfully coupled to either the primary or the secondary face of β-CD, where mono-6-amino-6-deoxy-β-CD or mono-3-amino-3-deoxy-β-CD reacted with the N-hydroxysuccinimide ester of 10,12-pentacosadiynoic acid. In this combinatorial system, the cylindrical β-cyclodextrin functions as a channel for the introduction of the cationic amino acids to the artificial membrane. The membrane perturbation and aggregation by the target amino acids could be exclusively visualized as a blue to red color change based on the responsive polydiacetylene domain. These interesting findings demonstrated that the developed β-CD conjugated PDA system may offer a new method of cell-penetrating mechanism, a promising vector system, as well as impact the production industry of arginine or lysine." @default.
- W2482027424 created "2016-08-23" @default.
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- W2482027424 date "2016-08-09" @default.
- W2482027424 modified "2023-10-14" @default.
- W2482027424 title "Polydiacetylenyl β-cyclodextrin based smart vesicles for colorimetric assay of arginine and lysine" @default.
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- W2482027424 doi "https://doi.org/10.1038/srep31115" @default.
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