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- W2482242521 abstract "I have been studying antibiotics since 1944. By 1951, penicillin, streptomycin, chloramphenicol, and tetracyclines were introduced into the clinical use and chemotheraphy of bacterial and rickettsia diseases were almost completely established. Thus antibiotic research was expanded to include antitumor antibiotics since about 1953. In about 1957, resistant strains appeared in hospital patients and the study of antibacterial antibiotics for the development of effective agent against resistant strains was started. By these studies many B-lactam antibiotics and amino-gylcoside antibiotics were studied and their derivatives and analogues were developed for the treatment of resistant infections. By 1965, organic chemistry had developed sufficiently to permit determination of structure of natural products very rapidly. This permitted optimization of the search for enzyme inhibitors, out of which the discovery of many compounds which have various pharmacological activities resulted. Enzyme inhibition research has expanded also to low molecular weight immunomodifiers which are useful in the" @default.
- W2482242521 created "2016-08-23" @default.
- W2482242521 creator A5013559735 @default.
- W2482242521 date "1984-04-24" @default.
- W2482242521 modified "2023-10-16" @default.
- W2482242521 title "Studies on New Microbial Secondary Metabolites with Potential Usefulness" @default.
- W2482242521 doi "https://doi.org/10.1021/bk-1984-0251.ch004" @default.
- W2482242521 hasPublicationYear "1984" @default.
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