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- W2482421597 abstract "Medium-chain alcohols are used to produce solvents, surfactants, lubricants, waxes, creams, and cosmetics. In this study, we engineered the oleaginous yeast Yarrowia lipolytica to produce 1-decanol from glucose. Expression of a fatty acyl-CoA reductase from Arabidopsis thaliana in strains of Y. lipolytica previously engineered to produce medium-chain fatty acids resulted in the production of 1-decanol. However, the resulting titers were very low (<10 mg/mL), most likely due to product catabolism. In addition, these strains produced small quantities of 1-hexadecanol and 1-octadecanol. Deleting the major peroxisome assembly factor Pex10 was found to significantly increase 1-decanol production, resulting in titers exceeding 500 mg/L. It also increased 1-hexadecanoland and 1-octadecanol titers, though the resulting increases were less than those for 1-decanol. These results demonstrate that Y. lipolytica can potentially be used for the industrial production of 1-decanol and other fatty alcohols from simple sugars." @default.
- W2482421597 created "2016-08-23" @default.
- W2482421597 creator A5005829958 @default.
- W2482421597 creator A5075223436 @default.
- W2482421597 date "2016-11-01" @default.
- W2482421597 modified "2023-10-11" @default.
- W2482421597 title "Production of 1-decanol by metabolically engineered Yarrowia lipolytica" @default.
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- W2482421597 doi "https://doi.org/10.1016/j.ymben.2016.07.011" @default.
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