Matches in SemOpenAlex for { <https://semopenalex.org/work/W2482433771> ?p ?o ?g. }
- W2482433771 endingPage "1919" @default.
- W2482433771 startingPage "1901" @default.
- W2482433771 abstract "MicroRNA (miRNA) deficiency impairs the generation of T follicular helper (Tfh) cells, but the contribution of individual miRNAs to this phenotype remains poorly understood. In this study, we performed deep sequencing analysis of miRNAs expressed in Tfh cells and identified a five-miRNA signature. Analyses of mutant mice deficient of these miRNAs revealed that miR-22 and miR-183/96/182 are dispensable, but miR-155 is essential for the generation and function of Tfh cells. miR-155 deficiency led to decreased proliferation specifically at the late stage of Tfh cell differentiation and reduced CD40 ligand (CD40L) expression on antigen-specific CD4+ T cells. Mechanistically, miR-155 repressed the expression of Peli1, a ubiquitin ligase that promotes the degradation of the NF-κB family transcription factor c-Rel, which controls cellular proliferation and CD40L expression. Therefore, our study identifies a novel miR-155–Peli1–c-Rel pathway that specifically regulates Tfh cell generation and function." @default.
- W2482433771 created "2016-08-23" @default.
- W2482433771 creator A5006886375 @default.
- W2482433771 creator A5013958114 @default.
- W2482433771 creator A5026282645 @default.
- W2482433771 creator A5027177090 @default.
- W2482433771 creator A5033988281 @default.
- W2482433771 creator A5044900502 @default.
- W2482433771 creator A5046404472 @default.
- W2482433771 creator A5047177237 @default.
- W2482433771 creator A5048670434 @default.
- W2482433771 creator A5050772776 @default.
- W2482433771 creator A5060640905 @default.
- W2482433771 creator A5062165742 @default.
- W2482433771 creator A5062966237 @default.
- W2482433771 creator A5067374707 @default.
- W2482433771 creator A5068531184 @default.
- W2482433771 creator A5068538895 @default.
- W2482433771 creator A5085536009 @default.
- W2482433771 date "2016-08-01" @default.
- W2482433771 modified "2023-10-17" @default.
- W2482433771 title "A miR-155–Peli1–c-Rel pathway controls the generation and function of T follicular helper cells" @default.
- W2482433771 cites W1596482914 @default.
- W2482433771 cites W1851971391 @default.
- W2482433771 cites W1916664742 @default.
- W2482433771 cites W1963818196 @default.
- W2482433771 cites W1966054625 @default.
- W2482433771 cites W1973053973 @default.
- W2482433771 cites W1973292340 @default.
- W2482433771 cites W1985533946 @default.
- W2482433771 cites W1990312329 @default.
- W2482433771 cites W1995468432 @default.
- W2482433771 cites W1997561112 @default.
- W2482433771 cites W2009749672 @default.
- W2482433771 cites W2014869583 @default.
- W2482433771 cites W2015200774 @default.
- W2482433771 cites W2021625284 @default.
- W2482433771 cites W2022206899 @default.
- W2482433771 cites W2023006000 @default.
- W2482433771 cites W2024381893 @default.
- W2482433771 cites W2028235759 @default.
- W2482433771 cites W2050509789 @default.
- W2482433771 cites W2052697521 @default.
- W2482433771 cites W2054281806 @default.
- W2482433771 cites W2059691278 @default.
- W2482433771 cites W2062903634 @default.
- W2482433771 cites W2067500883 @default.
- W2482433771 cites W2067567916 @default.
- W2482433771 cites W2071969437 @default.
- W2482433771 cites W2078657796 @default.
- W2482433771 cites W2079294041 @default.
- W2482433771 cites W2080727065 @default.
- W2482433771 cites W2083074884 @default.
- W2482433771 cites W2083187711 @default.
- W2482433771 cites W2085441977 @default.
- W2482433771 cites W2092547796 @default.
- W2482433771 cites W2096323879 @default.
- W2482433771 cites W2096589599 @default.
- W2482433771 cites W2098199767 @default.
- W2482433771 cites W2099295104 @default.
- W2482433771 cites W2110043839 @default.
- W2482433771 cites W2112024377 @default.
- W2482433771 cites W2127675457 @default.
- W2482433771 cites W2130486201 @default.
- W2482433771 cites W2133571578 @default.
- W2482433771 cites W2134202053 @default.
- W2482433771 cites W2134342374 @default.
- W2482433771 cites W2139016335 @default.
- W2482433771 cites W2139250592 @default.
- W2482433771 cites W2141875386 @default.
- W2482433771 cites W2147038308 @default.
- W2482433771 cites W2147495091 @default.
- W2482433771 cites W2152240340 @default.
- W2482433771 cites W2161870927 @default.
- W2482433771 cites W2162674813 @default.
- W2482433771 cites W2464468902 @default.
- W2482433771 doi "https://doi.org/10.1084/jem.20160204" @default.
- W2482433771 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4995083" @default.
- W2482433771 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27481129" @default.
- W2482433771 hasPublicationYear "2016" @default.
- W2482433771 type Work @default.
- W2482433771 sameAs 2482433771 @default.
- W2482433771 citedByCount "55" @default.
- W2482433771 countsByYear W24824337712016 @default.
- W2482433771 countsByYear W24824337712017 @default.
- W2482433771 countsByYear W24824337712018 @default.
- W2482433771 countsByYear W24824337712019 @default.
- W2482433771 countsByYear W24824337712020 @default.
- W2482433771 countsByYear W24824337712021 @default.
- W2482433771 countsByYear W24824337712022 @default.
- W2482433771 countsByYear W24824337712023 @default.
- W2482433771 crossrefType "journal-article" @default.
- W2482433771 hasAuthorship W2482433771A5006886375 @default.
- W2482433771 hasAuthorship W2482433771A5013958114 @default.
- W2482433771 hasAuthorship W2482433771A5026282645 @default.
- W2482433771 hasAuthorship W2482433771A5027177090 @default.
- W2482433771 hasAuthorship W2482433771A5033988281 @default.
- W2482433771 hasAuthorship W2482433771A5044900502 @default.