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- W2482494911 abstract "Human immunodeficiency virus (HIV) infection leads to complex alterations within the network of mucosal immune cells, which collectively cause mucosal immune activation. Mucosal immune activation in turn causes damage to the epithelial barrier via cytotoxic effects of CD8 T cells, inflammatory cytokines, and downregulation of cytokines and T cell subsets related to epithelial repair. Structural correlates of the ensuing epithelial barrier defect are increased epithelial apoptosis and altered expression of tight-junction proteins. The mucosal barrier defect leads to increased microbial translocation, which is a major driving force for the systemic immune activation. Systemic immune activation is considered a central pathomechanism in chronic HIV infection contributing to disease progression and to HIV-associated noninfectious comorbidity such as coronary heart disease, neurocognitive disorders, and liver disease. Therefore, there is a causal link between the HIV-induced intestinal mucosal barrier defect and disease progression, morbidity, and mortality of HIV-infected patients." @default.
- W2482494911 created "2016-08-23" @default.
- W2482494911 creator A5028123583 @default.
- W2482494911 creator A5031972677 @default.
- W2482494911 creator A5048936697 @default.
- W2482494911 date "2015-01-01" @default.
- W2482494911 modified "2023-10-01" @default.
- W2482494911 title "Microbial Translocation and the Effects of HIV/SIV Infection on Mucosal Barrier Function" @default.
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