FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2482555465> ?p ?o ?g. }

• W2482555465 endingPage "gkw667" @default.
• W2482555465 startingPage "gkw667" @default.
• W2482555465 abstract "The response to amino acid (AA) limitation of the entire aminoacyl-tRNA synthetase (ARS) gene family revealed that 16/20 of the genes encoding cytoplasmic-localized enzymes are transcriptionally induced by activating transcription factor 4 (Atf4) via C/ebp-Atf-Response-Element (CARE) enhancers. In contrast, only 4/19 of the genes encoding mitochondrial-localized ARSs were weakly induced. Most of the activated genes have a functional CARE near the transcription start site (TSS), but for others the CARE is downstream. Regardless of the location of CARE enhancer, for all ARS genes there was constitutive association of RNA polymerase II (Pol II) and the general transcription machinery near the TSS. However, for those genes with a downstream CARE, Atf4, C/ebp-homology protein (Chop), Pol II and TATA-binding protein exhibited enhanced recruitment to the CARE during AA limitation. Increased Atf4 binding regulated the association of elongation factors at both the promoter and the enhancer regions, and inhibition of cyclin-dependent kinase 9 (CDK9), that regulates these elongation factors, blocked induction of the AA-responsive ARS genes. Protein pull-down assays indicated that Atf4 directly interacts with CDK9 and its associated protein cyclin T1. The results demonstrate that AA availability modulates the ARS gene family through modulation of transcription elongation." @default.
• W2482555465 created "2016-08-23" @default.
• W2482555465 creator A5036104602 @default.
• W2482555465 creator A5053447705 @default.
• W2482555465 creator A5055098922 @default.
• W2482555465 creator A5055256688 @default.
• W2482555465 creator A5067555607 @default.
• W2482555465 creator A5067819993 @default.
• W2482555465 date "2016-07-28" @default.
• W2482555465 modified "2023-10-18" @default.
• W2482555465 title "The C/ebp-Atf response element (CARE) location reveals two distinct Atf4-dependent, elongation-mediated mechanisms for transcriptional induction of aminoacyl-tRNA synthetase genes in response to amino acid limitation" @default.
• W2482555465 cites W1489489167 @default.
• W2482555465 cites W1659944386 @default.
• W2482555465 cites W1686821153 @default.
• W2482555465 cites W1973085898 @default.
• W2482555465 cites W1980195461 @default.
• W2482555465 cites W1990142715 @default.
• W2482555465 cites W1991740019 @default.
• W2482555465 cites W1995226230 @default.
• W2482555465 cites W2007823610 @default.
• W2482555465 cites W2012451954 @default.
• W2482555465 cites W2016349604 @default.
• W2482555465 cites W2018232539 @default.
• W2482555465 cites W2021783951 @default.
• W2482555465 cites W2035500640 @default.
• W2482555465 cites W2050299992 @default.
• W2482555465 cites W2050988968 @default.
• W2482555465 cites W2053293102 @default.
• W2482555465 cites W2056535309 @default.
• W2482555465 cites W2056536853 @default.
• W2482555465 cites W2056664023 @default.
• W2482555465 cites W2056710038 @default.
• W2482555465 cites W2057228860 @default.
• W2482555465 cites W2057325460 @default.
• W2482555465 cites W2058083379 @default.
• W2482555465 cites W2064210252 @default.
• W2482555465 cites W2066533988 @default.
• W2482555465 cites W2074471441 @default.
• W2482555465 cites W2080666823 @default.
• W2482555465 cites W2089783252 @default.
• W2482555465 cites W2090952884 @default.
• W2482555465 cites W2094791437 @default.
• W2482555465 cites W2096010243 @default.
• W2482555465 cites W2103590517 @default.
• W2482555465 cites W2111099379 @default.
• W2482555465 cites W2111711854 @default.
• W2482555465 cites W2118337461 @default.
• W2482555465 cites W2123540119 @default.
• W2482555465 cites W2123654786 @default.
• W2482555465 cites W2124343649 @default.
• W2482555465 cites W2128845732 @default.
• W2482555465 cites W2131632095 @default.
• W2482555465 cites W2135229538 @default.
• W2482555465 cites W2140885472 @default.
• W2482555465 cites W2141948588 @default.
• W2482555465 cites W2144976262 @default.
• W2482555465 cites W2146747110 @default.
• W2482555465 cites W2148046166 @default.
• W2482555465 cites W2150009446 @default.
• W2482555465 cites W2150904710 @default.
• W2482555465 cites W2159158209 @default.
• W2482555465 cites W2162438404 @default.
• W2482555465 cites W2295037017 @default.
• W2482555465 cites W4210259626 @default.
• W2482555465 cites W6633754 @default.
• W2482555465 doi "https://doi.org/10.1093/nar/gkw667" @default.
• W2482555465 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5175342" @default.
• W2482555465 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27471030" @default.
• W2482555465 hasPublicationYear "2016" @default.
• W2482555465 type Work @default.
• W2482555465 sameAs 2482555465 @default.
• W2482555465 citedByCount "20" @default.
• W2482555465 countsByYear W24825554652017 @default.
• W2482555465 countsByYear W24825554652019 @default.
• W2482555465 countsByYear W24825554652020 @default.
• W2482555465 countsByYear W24825554652021 @default.
• W2482555465 countsByYear W24825554652022 @default.
• W2482555465 countsByYear W24825554652023 @default.
• W2482555465 crossrefType "journal-article" @default.
• W2482555465 hasAuthorship W2482555465A5036104602 @default.
• W2482555465 hasAuthorship W2482555465A5053447705 @default.
• W2482555465 hasAuthorship W2482555465A5055098922 @default.
• W2482555465 hasAuthorship W2482555465A5055256688 @default.
• W2482555465 hasAuthorship W2482555465A5067555607 @default.
• W2482555465 hasAuthorship W2482555465A5067819993 @default.
• W2482555465 hasBestOaLocation W24825554651 @default.
• W2482555465 hasConcept C101762097 @default.
• W2482555465 hasConcept C104317684 @default.
• W2482555465 hasConcept C111936080 @default.
• W2482555465 hasConcept C132376346 @default.
• W2482555465 hasConcept C138885662 @default.
• W2482555465 hasConcept C139124968 @default.
• W2482555465 hasConcept C150194340 @default.
• W2482555465 hasConcept C153911025 @default.
• W2482555465 hasConcept C179926584 @default.
• W2482555465 hasConcept C2780900454 @default.
• W2482555465 hasConcept C41895202 @default.
• W2482555465 hasConcept C55493867 @default.

• next