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- W2482632416 abstract "Toll-like receptors (TLRs) are pattern recognition proteins found both on cell surfaces as well as within intracellular compartments. Originally defined on the basis of their homology to the Drosophila protein Toll, which is important in the fruit fly defense against fungal infections [1], mammalian TLRs were first demonstrated to be critical in determining whether animals develop shock after challenge with bacterial lipopolysaccharide (LPS). The interaction between E.coli LPS and TLR4 leads to a series of events resulting in the production of cytokines and inflammatory mediators that affect vascular permeability and that ultimately cause a decrease in blood pressure and death of the animal. Subsequent studies have revealed a role for TLRs in the immune responses not only to bacteria but also to fungi, parasites, and viruses." @default.
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- W2482632416 date "2008-10-16" @default.
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- W2482632416 title "Role of Toll-like receptors in neurotropic viral infections" @default.
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- W2482632416 doi "https://doi.org/10.1017/cbo9780511541728.020" @default.
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