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- W2482646598 abstract "Publisher Summary The central feature of Alzheimer's disease is a remarkably specific loss of cognitive functions in affected individuals. The evidence that links Alzheimer's disease neurodegeneration and pathology with APP and/or its Aβ-containing derivatives is the early finding that the APP gene is on chromosome 21, for virtually all individuals trisomic for this chromosome will show AD-like neurodegeneration by the age of 40. It is found that PC12 cells transfected with a retroviral recombinant expressing the carboxyterminal 100 amino acids of APP die when they are induced to acquire a neuronal phenotype with nerve growth factor (NGF), while transfectants expressing exogenous APP-695 or Aβ differentiate normally without cell loss when exposed to NGF. Transplantation of APP-C100-transfected PC12 cells into the brains of newborn mice results in neuropathology. Transgenic mice expressing APP-C100 in the brain display Alzheimer's disease-like neuropathology. Expression of APP-C100 in the brain leads to massive neurodegeneration in aged transgenic mice." @default.
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- W2482646598 date "1995-01-01" @default.
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- W2482646598 title "Genetic animal models for Alzheimer's disease" @default.
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