Matches in SemOpenAlex for { <https://semopenalex.org/work/W2482848503> ?p ?o ?g. }
- W2482848503 abstract "Publisher SummaryThis chapter summarizes research on the cyclodiene and related insecticides, which led to an appreciation of their structure–toxicity relationships and in the end to an understanding of their mode of action as noncompetitive antagonists acting in the chloride ion channel of the gamma-aminobutyric acid (GABA) A-receptor. The history of lindane and the cyclodiene-related group (collectively polychloro-cycloalkanes, PCCAs) is complex, partly because of the variety of commercially viable insecticides that arose from the early discoveries. Lindane was soon found to be biodegradable but the strongly residual nature of the cyclodiene insecticides and the discovery that aldrin was converted into its stable epoxide, dieldrin, led to the view that these insecticides were inert. It is unfortunate that due to the high potency of lindane, t-HCH could be used directly and extensively as a practical insecticide, resulting in contamination of the environment with the remaining inactive isomers; lindane itself is relatively biodegradable and continues to be a valuable insecticide. Insect poisoning by commercial cyclodienes was not at first recognized to be reversible because their persistence in the tissues led to eventual death due to desiccation and starvation, without any recovery. Housefly poisoning by HCE was noted to be reversible, however, and even insects poisoned with HCE/sesoxane combinations would occasionally recover after prolonged periods of knockdown. The commercially successful insecticide fipronil appears to fulfill these expectations and other new chemicals are likely to follow. Rapid advances in molecular biology, will ensure a prominent use for the PCCA insecticides and the newer chemicals with related actions, as tools in these explorations." @default.
- W2482848503 created "2016-08-23" @default.
- W2482848503 creator A5076833927 @default.
- W2482848503 date "2010-01-01" @default.
- W2482848503 modified "2023-09-25" @default.
- W2482848503 title "Interactions with the Gamma-Aminobutyric Acid A-Receptor" @default.
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