Matches in SemOpenAlex for { <https://semopenalex.org/work/W2482953755> ?p ?o ?g. }
Showing items 1 to 92 of
92
with 100 items per page.
- W2482953755 abstract "Background: Esophagus cancer is the sixth most common cause of death all over the world. This type of cancer is divided into two histological subtypes: Esophagus squamous cell carcinoma and Adeno-carcinoma, the first type of this type of cancer approximately include 90% of esophageal cancers in Asian countries. While radio therapy, chemotherapy and surgery are useful in treating, few people are survived. Therefore, it is need to molecular study to predict and prevent this cancer. EZH2 gene is a member of poly comb group proteins, and with other proteins of this group act as epigenetic regulators and have principle role in cellular functions. Objectives: In this study our aim was to evaluate the impact of EZH2 silencing on TSLP gene. Materials and Methods: For constantly silencing of EZH2 gene in KYSE-30, we used shRNA in retroviral vector. After viral production in HEK293T cell line, the cells of esophagus squamous cell carcinoma were transduced with viral packages. Silencing of EZH2 gene and the expression of TSLP were evaluated with real- time PCR. Results: By using retroviral EZH2 shRNA, the expression of EZH2 reduced over 2.5 fold change in KYSE-30. TSLP gene expression reduced over 2 fold change after EZH2 gene silencing in KYSE-30. Conclusions: Regarding the stablishing of KYSE-30 cell line with EZH2 silenced gene, Our results showed that the decrease of EZH2 gene expression cause change of downstream genes expression that will be eective on molecular treatment of ESCC." @default.
- W2482953755 created "2016-08-23" @default.
- W2482953755 creator A5018570666 @default.
- W2482953755 creator A5079002317 @default.
- W2482953755 creator A5082428766 @default.
- W2482953755 date "2016-06-18" @default.
- W2482953755 modified "2023-10-14" @default.
- W2482953755 title "Down-Regulation of TSLP After EZH2 Silencing in ESCC Cell Line" @default.
- W2482953755 cites W1512983238 @default.
- W2482953755 cites W1522506940 @default.
- W2482953755 cites W1535682759 @default.
- W2482953755 cites W1558665965 @default.
- W2482953755 cites W1707020432 @default.
- W2482953755 cites W1848841587 @default.
- W2482953755 cites W1922231519 @default.
- W2482953755 cites W1984529564 @default.
- W2482953755 cites W2003313289 @default.
- W2482953755 cites W2016736773 @default.
- W2482953755 cites W2023010212 @default.
- W2482953755 cites W2027073895 @default.
- W2482953755 cites W2039948198 @default.
- W2482953755 cites W2059058989 @default.
- W2482953755 cites W2101439590 @default.
- W2482953755 cites W2108381095 @default.
- W2482953755 cites W2114318954 @default.
- W2482953755 cites W2115105515 @default.
- W2482953755 cites W2122128999 @default.
- W2482953755 cites W2124759812 @default.
- W2482953755 cites W2125496315 @default.
- W2482953755 cites W2134308253 @default.
- W2482953755 cites W2140148690 @default.
- W2482953755 cites W2149336558 @default.
- W2482953755 cites W2162803006 @default.
- W2482953755 cites W2169367928 @default.
- W2482953755 cites W2278196739 @default.
- W2482953755 cites W2299952444 @default.
- W2482953755 cites W2342065826 @default.
- W2482953755 doi "https://doi.org/10.17795/jbm-5852" @default.
- W2482953755 hasPublicationYear "2016" @default.
- W2482953755 type Work @default.
- W2482953755 sameAs 2482953755 @default.
- W2482953755 citedByCount "1" @default.
- W2482953755 countsByYear W24829537552021 @default.
- W2482953755 crossrefType "journal-article" @default.
- W2482953755 hasAuthorship W2482953755A5018570666 @default.
- W2482953755 hasAuthorship W2482953755A5079002317 @default.
- W2482953755 hasAuthorship W2482953755A5082428766 @default.
- W2482953755 hasConcept C104317684 @default.
- W2482953755 hasConcept C119056186 @default.
- W2482953755 hasConcept C185592680 @default.
- W2482953755 hasConcept C198352243 @default.
- W2482953755 hasConcept C2524010 @default.
- W2482953755 hasConcept C33923547 @default.
- W2482953755 hasConcept C41091548 @default.
- W2482953755 hasConcept C50171091 @default.
- W2482953755 hasConcept C502942594 @default.
- W2482953755 hasConcept C54355233 @default.
- W2482953755 hasConcept C81885089 @default.
- W2482953755 hasConcept C86803240 @default.
- W2482953755 hasConcept C95444343 @default.
- W2482953755 hasConceptScore W2482953755C104317684 @default.
- W2482953755 hasConceptScore W2482953755C119056186 @default.
- W2482953755 hasConceptScore W2482953755C185592680 @default.
- W2482953755 hasConceptScore W2482953755C198352243 @default.
- W2482953755 hasConceptScore W2482953755C2524010 @default.
- W2482953755 hasConceptScore W2482953755C33923547 @default.
- W2482953755 hasConceptScore W2482953755C41091548 @default.
- W2482953755 hasConceptScore W2482953755C50171091 @default.
- W2482953755 hasConceptScore W2482953755C502942594 @default.
- W2482953755 hasConceptScore W2482953755C54355233 @default.
- W2482953755 hasConceptScore W2482953755C81885089 @default.
- W2482953755 hasConceptScore W2482953755C86803240 @default.
- W2482953755 hasConceptScore W2482953755C95444343 @default.
- W2482953755 hasIssue "2" @default.
- W2482953755 hasLocation W24829537551 @default.
- W2482953755 hasOpenAccess W2482953755 @default.
- W2482953755 hasPrimaryLocation W24829537551 @default.
- W2482953755 hasRelatedWork W1187071477 @default.
- W2482953755 hasRelatedWork W1971981721 @default.
- W2482953755 hasRelatedWork W2153431977 @default.
- W2482953755 hasRelatedWork W2153734475 @default.
- W2482953755 hasRelatedWork W2263927213 @default.
- W2482953755 hasRelatedWork W2272538773 @default.
- W2482953755 hasRelatedWork W2566318589 @default.
- W2482953755 hasRelatedWork W2591985759 @default.
- W2482953755 hasRelatedWork W2921421046 @default.
- W2482953755 hasRelatedWork W4235684485 @default.
- W2482953755 hasVolume "1" @default.
- W2482953755 isParatext "false" @default.
- W2482953755 isRetracted "false" @default.
- W2482953755 magId "2482953755" @default.
- W2482953755 workType "article" @default.