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• W2482968401 abstract "Silicosis is a lung disease that results from inhalation of respiratory particles of some crystalline forms of the mineral silica. Silicosis can be of an acute or chronic form depending on the exposure dose rate. Acute silicosis is associated with an infiltration of inflammatory cells, alveolar proteinosis, and diffuse fibrosis. Chronic simple silicosis is associated with an inflammation and a nodular fibrosis (silicotic nodules). Either form of silicosis can continue to progress after exposure has been discontinued. There are eight different crystalline silica polymorphs that differ in their inherent toxicity and propensity to cause silicosis. Based on in vitro and in vivo studies, – tridymite, cristobalite, and quartz are polymorphs with high toxicity, while coesite and stishovite are crystalline silica polymorphs that are relatively much less toxic. The other silica polymorphs have not been studied in any detail. The mechanism by which crystalline silica causes silicosis appears to be multifactorial. Hydrogen bonding of silanol groups present on the surface of crystalline silica with constituents in cell membranes contributes to the cytotoxic effect and tissues injury produced of crystalline silica. In addition, the surface chemistry of crystalline silica can result in the production of reactive oxygen species and this is also believed to contribute to the toxic effects of this mineral. Importantly, the surface structure (crystalline vs. amorphous), composition (metals present in the silica, e.g., iron), or compounds that can be associated with crystalline silica (iron) can influence its bioactivity. In addition to a direct cytotoxic action, crystalline silica can activate cells to release proinflammatory and fibrosis-producing cytokines. This may occur through a direct activation of cell surface receptors (e.g., scavenger receptors) or from the ability of crystalline silica to evoke redox changes within inflammatory cells and epithelial cells activating intracellular signal pathways. Epidemiology studies have revealed an association between crystalline silica exposure and/or silicosis and increased lung cancer risk. While the mechanism underlying this association has not be elucidated, recent studies indicate that inflammation associated with fibrogenic exposure levels of crystalline silica may contribute to the carcinogenic response. Specifically, it has been proposed that inflammatory cell-derived oxidants cause mutations in epithelial cells that are induced to proliferate in response to growth factors also produced by inflammatory cells. The combination of chronic inflammation and cell proliferation is responsible for the association between lung cancer and crystalline silica exposure." @default.
• W2482968401 created "2016-08-23" @default.
• W2482968401 creator A5025218521 @default.
• W2482968401 creator A5041802127 @default.
• W2482968401 date "2010-01-01" @default.
• W2482968401 modified "2023-09-26" @default.
• W2482968401 title "Crystalline Silica and Silicosis" @default.
• W2482968401 cites W110280024 @default.
• W2482968401 cites W121781868 @default.
• W2482968401 cites W1501564271 @default.
• W2482968401 cites W1519731306 @default.
• W2482968401 cites W1543631408 @default.
• W2482968401 cites W1597643123 @default.
• W2482968401 cites W1598875012 @default.
• W2482968401 cites W1835822066 @default.
• W2482968401 cites W1874564452 @default.
• W2482968401 cites W1923921388 @default.
• W2482968401 cites W1946796054 @default.
• W2482968401 cites W1965129842 @default.
• W2482968401 cites W1965344276 @default.
• W2482968401 cites W1968140100 @default.
• W2482968401 cites W1968823758 @default.
• W2482968401 cites W1970218284 @default.
• W2482968401 cites W1974678821 @default.
• W2482968401 cites W1975672902 @default.
• W2482968401 cites W1982504819 @default.
• W2482968401 cites W1983238489 @default.
• W2482968401 cites W1985469984 @default.
• W2482968401 cites W1985645054 @default.
• W2482968401 cites W1987767047 @default.
• W2482968401 cites W1988742153 @default.
• W2482968401 cites W1995273399 @default.
• W2482968401 cites W1995495127 @default.
• W2482968401 cites W1998092895 @default.
• W2482968401 cites W2000396131 @default.
• W2482968401 cites W2005659566 @default.
• W2482968401 cites W2006556473 @default.
• W2482968401 cites W2007166597 @default.
• W2482968401 cites W2008683628 @default.
• W2482968401 cites W2009372972 @default.
• W2482968401 cites W2009444484 @default.
• W2482968401 cites W2009821565 @default.
• W2482968401 cites W2010055022 @default.
• W2482968401 cites W2010270130 @default.
• W2482968401 cites W2010328277 @default.
• W2482968401 cites W2010413692 @default.
• W2482968401 cites W2012225498 @default.
• W2482968401 cites W2013048589 @default.
• W2482968401 cites W2013105195 @default.
• W2482968401 cites W2015165966 @default.
• W2482968401 cites W2016523675 @default.
• W2482968401 cites W2020994415 @default.
• W2482968401 cites W2021169193 @default.
• W2482968401 cites W2024416061 @default.
• W2482968401 cites W2026644554 @default.
• W2482968401 cites W2028850913 @default.
• W2482968401 cites W2036755906 @default.
• W2482968401 cites W2037727844 @default.
• W2482968401 cites W2039351380 @default.
• W2482968401 cites W2041290673 @default.
• W2482968401 cites W2043172656 @default.
• W2482968401 cites W2046909725 @default.
• W2482968401 cites W2046998600 @default.
• W2482968401 cites W2047882822 @default.
• W2482968401 cites W2047988218 @default.
• W2482968401 cites W2048378664 @default.
• W2482968401 cites W2052202105 @default.
• W2482968401 cites W2054117872 @default.
• W2482968401 cites W2054399944 @default.
• W2482968401 cites W2057359257 @default.
• W2482968401 cites W2057820430 @default.
• W2482968401 cites W2058176586 @default.
• W2482968401 cites W2061345139 @default.
• W2482968401 cites W2062711583 @default.
• W2482968401 cites W2066591745 @default.
• W2482968401 cites W2069245663 @default.
• W2482968401 cites W2077207863 @default.
• W2482968401 cites W2086125827 @default.
• W2482968401 cites W2088558722 @default.
• W2482968401 cites W2088609052 @default.
• W2482968401 cites W2098381985 @default.
• W2482968401 cites W2099104193 @default.
• W2482968401 cites W2101245680 @default.
• W2482968401 cites W2102255946 @default.
• W2482968401 cites W2110824853 @default.
• W2482968401 cites W2111803376 @default.
• W2482968401 cites W2117632018 @default.
• W2482968401 cites W2128421447 @default.
• W2482968401 cites W2140831739 @default.
• W2482968401 cites W2141422576 @default.
• W2482968401 cites W2144565206 @default.
• W2482968401 cites W2148889127 @default.
• W2482968401 cites W2151114770 @default.
• W2482968401 cites W2164983049 @default.
• W2482968401 cites W2166781237 @default.
• W2482968401 cites W2167507720 @default.
• W2482968401 cites W2168992580 @default.
• W2482968401 cites W2169992413 @default.

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