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- W2483048135 abstract "The present protocol introduces a single-chain probe carrying a functional peptide in the N-terminal domain of the androgen receptor (AR NTD) for illuminating androgenicity of ligands. In the single-chain probe, a functional peptide in the AR NTD was genetically fused to the ligand-binding domain of AR (AR LBD) via a flexible linker, and then sandwiched between the N- and C-terminal fragments of split-firefly luciferase (FLuc) dissected at D415. This single-chain probe exerts (1) a high signal-to-background ratio and (2) sensitive discrimination between agonists and antagonists, where the dimerization of AR LBD is not involved. The present protocol guides a fundamental methodology on how to discriminate weak protein-protein (peptide) binding, and provides a new insight into the intramolecular folding inside monomeric AR." @default.
- W2483048135 created "2016-08-23" @default.
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- W2483048135 date "2016-01-01" @default.
- W2483048135 modified "2023-09-26" @default.
- W2483048135 title "Single-Chain Probes for Illuminating Androgenicity of Chemicals" @default.
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- W2483048135 doi "https://doi.org/10.1007/978-1-4939-3813-1_11" @default.
- W2483048135 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27424901" @default.
- W2483048135 hasPublicationYear "2016" @default.
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