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- W2483052336 endingPage "621" @default.
- W2483052336 startingPage "577" @default.
- W2483052336 abstract "FK506 (tacrolimus) is a natural product of Streptomyces tukubaensis and is essentially a 23-membered macrolide antibiotic that contains a unique hemiketal-masked α,β-diketo amide moiety. It has mode of action and toxicity profile similar to those of cyclosporin A (CsA). The use of CsA has resulted in remarkable increase of survival of all organ allografts and has led to increase in the number of kidney, liver, cardiac, and bone marrow transplants, thus revolutionizing transplantation surgery, both in terms of efficiency and quality of life of the patient. FK506 is more potent immunosuppressant than CsA and is approved for the treatment and prevention of kidney transplant rejection. It is noted that despite their structural differences, CsA and FK506, immunosuppressants, exhibit a nearly identical spectrum of action on T lymphocytes. In contrast, regardless of their structural similarity, FK506 and rapamycin exhibit quite different spectra of action on T lymphocytes, though both FK506 and rapamycin are powerful immunosuppressants. CsA effectively inhibits the enzymatic activity of cyclophilin, whereas FK506 and rapamycin inhibit the activity of FK506-binding protein." @default.
- W2483052336 created "2016-08-23" @default.
- W2483052336 creator A5051273148 @default.
- W2483052336 date "2003-01-01" @default.
- W2483052336 modified "2023-09-26" @default.
- W2483052336 title "Mode of Action of FK506 and Rapamycin" @default.
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