FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2483065718> ?p ?o ?g. }

• W2483065718 endingPage "1106" @default.
• W2483065718 startingPage "1094" @default.
• W2483065718 abstract "Identifying small molecules to activate the Oct-4/Sox2-derived pluripotency network represents a hopeful and safe method to pluripotency without genetic manipulation. Luteolin and apigenin, two major bioactive flavonoids, enhance reprogramming efficiency and increase expression of Oct-4/Sox2/c-Myc, albeit the detailed mechanism regulating pluripotency in dental-derived cells remains unknown. In the present study, to elucidate the effect of luteolin/apigenin on pluripotency of periodontal ligament cells (PDLCs) through interaction with downstream signals, we examined cell cycle, proliferation, apoptosis, expression of Oct-4/Sox2/c-Myc, and multilineage differentiation of PDLCs with luteolin/apigenin treatment. Moreover, we profiled the differentially expressed pluripotency genes by PCR arrays. Our results demonstrated that luteolin/apigenin restrained cell proliferation, increased apoptosis, and arrested PDLCs in G2/M and S phase. Luteolin and apigenin activated expression of Oct-4, Sox2, and c-Myc in a time- and dose-dependent pattern, and repressed lineage-specific differentiation. PCR arrays profiled multiple signals in PDLCs with luteolin/apigenin treatment, among which NFATc1 was the major upregulated gene. Notably, blocking of the NFATc1 signal with INCA-6 significantly decreased mRNA and protein expression of Oct-4, Sox2, and c-Myc in PDLCs with luteolin/apigenin treatment, indicating that NFATc1 may act as an upstream modulator of Oct-4/Sox2 signal. Taken together, this study showed that luteolin and apigenin effectively maintain pluripotency of PDLCs through activation of Oct-4/Sox2 signal via NFATc1." @default.
• W2483065718 created "2016-08-23" @default.
• W2483065718 creator A5016333272 @default.
• W2483065718 creator A5018693731 @default.
• W2483065718 creator A5022895653 @default.
• W2483065718 creator A5090594172 @default.
• W2483065718 creator A5090942898 @default.
• W2483065718 date "2016-08-09" @default.
• W2483065718 modified "2023-09-27" @default.
• W2483065718 title "Luteolin and apigenin activate the Oct-4/Sox2 signal via NFATc1 in human periodontal ligament cells" @default.
• W2483065718 cites W1181840000 @default.
• W2483065718 cites W1606595372 @default.
• W2483065718 cites W1611548009 @default.
• W2483065718 cites W1611629097 @default.
• W2483065718 cites W1970192935 @default.
• W2483065718 cites W1979264391 @default.
• W2483065718 cites W1989482315 @default.
• W2483065718 cites W1997278755 @default.
• W2483065718 cites W1998241118 @default.
• W2483065718 cites W1999519607 @default.
• W2483065718 cites W2007568547 @default.
• W2483065718 cites W2009730662 @default.
• W2483065718 cites W2014511122 @default.
• W2483065718 cites W2015254140 @default.
• W2483065718 cites W2015967888 @default.
• W2483065718 cites W2020915224 @default.
• W2483065718 cites W2030187942 @default.
• W2483065718 cites W2039625808 @default.
• W2483065718 cites W2042556846 @default.
• W2483065718 cites W2045203256 @default.
• W2483065718 cites W2045417725 @default.
• W2483065718 cites W2052227589 @default.
• W2483065718 cites W2056401732 @default.
• W2483065718 cites W2064559242 @default.
• W2483065718 cites W2070785261 @default.
• W2483065718 cites W2070789023 @default.
• W2483065718 cites W2085256219 @default.
• W2483065718 cites W2088127789 @default.
• W2483065718 cites W2105552270 @default.
• W2483065718 cites W2117112486 @default.
• W2483065718 cites W2125987139 @default.
• W2483065718 cites W2139867317 @default.
• W2483065718 cites W2142884307 @default.
• W2483065718 cites W2163101786 @default.
• W2483065718 cites W2287931631 @default.
• W2483065718 cites W2411274954 @default.
• W2483065718 cites W2418944125 @default.
• W2483065718 cites W266883849 @default.
• W2483065718 doi "https://doi.org/10.1002/cbin.10648" @default.
• W2483065718 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27449921" @default.
• W2483065718 hasPublicationYear "2016" @default.
• W2483065718 type Work @default.
• W2483065718 sameAs 2483065718 @default.
• W2483065718 citedByCount "13" @default.
• W2483065718 countsByYear W24830657182017 @default.
• W2483065718 countsByYear W24830657182018 @default.
• W2483065718 countsByYear W24830657182019 @default.
• W2483065718 countsByYear W24830657182020 @default.
• W2483065718 countsByYear W24830657182021 @default.
• W2483065718 countsByYear W24830657182022 @default.
• W2483065718 countsByYear W24830657182023 @default.
• W2483065718 crossrefType "journal-article" @default.
• W2483065718 hasAuthorship W2483065718A5016333272 @default.
• W2483065718 hasAuthorship W2483065718A5018693731 @default.
• W2483065718 hasAuthorship W2483065718A5022895653 @default.
• W2483065718 hasAuthorship W2483065718A5090594172 @default.
• W2483065718 hasAuthorship W2483065718A5090942898 @default.
• W2483065718 hasConcept C104317684 @default.
• W2483065718 hasConcept C145103041 @default.
• W2483065718 hasConcept C153911025 @default.
• W2483065718 hasConcept C185592680 @default.
• W2483065718 hasConcept C2776080593 @default.
• W2483065718 hasConcept C2777933648 @default.
• W2483065718 hasConcept C2778004101 @default.
• W2483065718 hasConcept C2778609962 @default.
• W2483065718 hasConcept C2779054382 @default.
• W2483065718 hasConcept C2781263971 @default.
• W2483065718 hasConcept C55493867 @default.
• W2483065718 hasConcept C86803240 @default.
• W2483065718 hasConcept C95444343 @default.
• W2483065718 hasConceptScore W2483065718C104317684 @default.
• W2483065718 hasConceptScore W2483065718C145103041 @default.
• W2483065718 hasConceptScore W2483065718C153911025 @default.
• W2483065718 hasConceptScore W2483065718C185592680 @default.
• W2483065718 hasConceptScore W2483065718C2776080593 @default.
• W2483065718 hasConceptScore W2483065718C2777933648 @default.
• W2483065718 hasConceptScore W2483065718C2778004101 @default.
• W2483065718 hasConceptScore W2483065718C2778609962 @default.
• W2483065718 hasConceptScore W2483065718C2779054382 @default.
• W2483065718 hasConceptScore W2483065718C2781263971 @default.
• W2483065718 hasConceptScore W2483065718C55493867 @default.
• W2483065718 hasConceptScore W2483065718C86803240 @default.
• W2483065718 hasConceptScore W2483065718C95444343 @default.
• W2483065718 hasIssue "10" @default.
• W2483065718 hasLocation W24830657181 @default.
• W2483065718 hasLocation W24830657182 @default.
• W2483065718 hasOpenAccess W2483065718 @default.
• W2483065718 hasPrimaryLocation W24830657181 @default.

• next