FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2483092283> ?p ?o ?g. }

• W2483092283 abstract "Background & Aim: We recently analyzed 12 pairs of African American CRC tumors and their matched normal tissue using whole exome sequencing and established a panel of novel mutations that are potentially useful for the detection of CRC in this population. In this study, we examined APC, MSH3, and MSH6 mutations using targeted exome sequencing (TES) to determine distinctive mutations frequencies and their chronology in the neoplastic transformation. Materials & Methods: A total of 140 colon samples: (30 normal, 21 adenomas, 33 advanced adenomas & 56 tumors collected from African Americans were used as our discovery set on an Ion Torrent platform. A subset of 36 samples were used as validation set on an Illumina platform. Bioinformatic analysis was performed on both sets of data. Common mutations were considered validated. Results: Two novel MSH6 mutations were validated. Four known mutations in MSH3 were validated and were located in nonsynonymous (exon 10) and 1synonomous mutation (exon 18). As for the APC, 20 mutations were validated include 4 novel mutations. The novel mutations were 3 stopgain and 1 nonsynonymous located at the EB1 binding site, in the mutational cluster region (MCR), and at the 15 Amino Acid repeat. Conclusion: We here defined novel mutations that target DNA MMR and APC genes in African Americans with colorectal lesions. Greater frequency of mutations in cells defective for DNA repair and APC genes is an advantage in cell growth and genetic instability and relevant to the initiating events of colon tumorigenesis. Citation Format: Hassan Ashktorab, Hamed Azimi, Mike Nickerson, Sara Bass, Joseph Boland, Meredith Yeager, Sudhir Varma, Mohamed Daremipouran, Zaki Sherif, Shima Ghavimi, Babak Shokrani, Edward Lee, Adeyinka Laiyemo, Hassan Brim. Targeted sequencing revealed distinctive and pathogenic mutations in African Americans with colorectal cancer. [abstract]. In: Proceedings of the 107th Annual Meeting of the American Association for Cancer Research; 2016 Apr 16-20; New Orleans, LA. Philadelphia (PA): AACR; Cancer Res 2016;76(14 Suppl):Abstract nr 4488." @default.
• W2483092283 created "2016-08-23" @default.
• W2483092283 creator A5024787500 @default.
• W2483092283 creator A5028538999 @default.
• W2483092283 creator A5034693159 @default.
• W2483092283 creator A5041280927 @default.
• W2483092283 creator A5044909526 @default.
• W2483092283 creator A5044999064 @default.
• W2483092283 creator A5056991781 @default.
• W2483092283 creator A5067033282 @default.
• W2483092283 creator A5068824076 @default.
• W2483092283 creator A5069806544 @default.
• W2483092283 creator A5072551621 @default.
• W2483092283 creator A5083409124 @default.
• W2483092283 creator A5086799366 @default.
• W2483092283 creator A5087166167 @default.
• W2483092283 date "2016-07-15" @default.
• W2483092283 modified "2023-10-17" @default.
• W2483092283 title "Abstract 4488: Targeted sequencing revealed distinctive and pathogenic mutations in African Americans with colorectal cancer" @default.
• W2483092283 doi "https://doi.org/10.1158/1538-7445.am2016-4488" @default.
• W2483092283 hasPublicationYear "2016" @default.
• W2483092283 type Work @default.
• W2483092283 sameAs 2483092283 @default.
• W2483092283 citedByCount "0" @default.
• W2483092283 crossrefType "proceedings-article" @default.
• W2483092283 hasAuthorship W2483092283A5024787500 @default.
• W2483092283 hasAuthorship W2483092283A5028538999 @default.
• W2483092283 hasAuthorship W2483092283A5034693159 @default.
• W2483092283 hasAuthorship W2483092283A5041280927 @default.
• W2483092283 hasAuthorship W2483092283A5044909526 @default.
• W2483092283 hasAuthorship W2483092283A5044999064 @default.
• W2483092283 hasAuthorship W2483092283A5056991781 @default.
• W2483092283 hasAuthorship W2483092283A5067033282 @default.
• W2483092283 hasAuthorship W2483092283A5068824076 @default.
• W2483092283 hasAuthorship W2483092283A5069806544 @default.
• W2483092283 hasAuthorship W2483092283A5072551621 @default.
• W2483092283 hasAuthorship W2483092283A5083409124 @default.
• W2483092283 hasAuthorship W2483092283A5086799366 @default.
• W2483092283 hasAuthorship W2483092283A5087166167 @default.
• W2483092283 hasConcept C102306862 @default.
• W2483092283 hasConcept C104317684 @default.
• W2483092283 hasConcept C10590036 @default.
• W2483092283 hasConcept C121608353 @default.
• W2483092283 hasConcept C141231307 @default.
• W2483092283 hasConcept C149904235 @default.
• W2483092283 hasConcept C16671776 @default.
• W2483092283 hasConcept C2776674815 @default.
• W2483092283 hasConcept C2908647359 @default.
• W2483092283 hasConcept C36823959 @default.
• W2483092283 hasConcept C501734568 @default.
• W2483092283 hasConcept C502942594 @default.
• W2483092283 hasConcept C51679486 @default.
• W2483092283 hasConcept C526805850 @default.
• W2483092283 hasConcept C54355233 @default.
• W2483092283 hasConcept C555283112 @default.
• W2483092283 hasConcept C60748783 @default.
• W2483092283 hasConcept C71924100 @default.
• W2483092283 hasConcept C75563809 @default.
• W2483092283 hasConcept C86803240 @default.
• W2483092283 hasConcept C99454951 @default.
• W2483092283 hasConceptScore W2483092283C102306862 @default.
• W2483092283 hasConceptScore W2483092283C104317684 @default.
• W2483092283 hasConceptScore W2483092283C10590036 @default.
• W2483092283 hasConceptScore W2483092283C121608353 @default.
• W2483092283 hasConceptScore W2483092283C141231307 @default.
• W2483092283 hasConceptScore W2483092283C149904235 @default.
• W2483092283 hasConceptScore W2483092283C16671776 @default.
• W2483092283 hasConceptScore W2483092283C2776674815 @default.
• W2483092283 hasConceptScore W2483092283C2908647359 @default.
• W2483092283 hasConceptScore W2483092283C36823959 @default.
• W2483092283 hasConceptScore W2483092283C501734568 @default.
• W2483092283 hasConceptScore W2483092283C502942594 @default.
• W2483092283 hasConceptScore W2483092283C51679486 @default.
• W2483092283 hasConceptScore W2483092283C526805850 @default.
• W2483092283 hasConceptScore W2483092283C54355233 @default.
• W2483092283 hasConceptScore W2483092283C555283112 @default.
• W2483092283 hasConceptScore W2483092283C60748783 @default.
• W2483092283 hasConceptScore W2483092283C71924100 @default.
• W2483092283 hasConceptScore W2483092283C75563809 @default.
• W2483092283 hasConceptScore W2483092283C86803240 @default.
• W2483092283 hasConceptScore W2483092283C99454951 @default.
• W2483092283 hasLocation W24830922831 @default.
• W2483092283 hasOpenAccess W2483092283 @default.
• W2483092283 hasPrimaryLocation W24830922831 @default.
• W2483092283 hasRelatedWork W1483453712 @default.
• W2483092283 hasRelatedWork W1983698066 @default.
• W2483092283 hasRelatedWork W2000569716 @default.
• W2483092283 hasRelatedWork W2042208755 @default.
• W2483092283 hasRelatedWork W2085289502 @default.
• W2483092283 hasRelatedWork W2122704637 @default.
• W2483092283 hasRelatedWork W2188203706 @default.
• W2483092283 hasRelatedWork W2253567178 @default.
• W2483092283 hasRelatedWork W2303232007 @default.
• W2483092283 hasRelatedWork W2317164610 @default.
• W2483092283 hasRelatedWork W2372844112 @default.
• W2483092283 hasRelatedWork W2439772698 @default.
• W2483092283 hasRelatedWork W2484726455 @default.
• W2483092283 hasRelatedWork W2495673209 @default.
• W2483092283 hasRelatedWork W2586993857 @default.
• W2483092283 hasRelatedWork W2604035013 @default.

• next