FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2483369799> ?p ?o ?g. }

• W2483369799 endingPage "102" @default.
• W2483369799 startingPage "82" @default.
• W2483369799 abstract "Cell-based therapy, and more particularly the use of stem cells, represents one of the most promising areas of research for the future of regenerative medicine. Bones provide the scaffolding upon which the body is built and the development of methods to cure bone damages or anomalies is of importance for the clinic. Albeit bones have the capacity to self-repair in response to traumatic injury, numerous bone-associated diseases/ traumas, in which the regenerative process is compromised or insuffi cient for self-healing, remain incurable. The bone regeneration process is made of a succession of physiological events well orchestrated, spatially and temporally, by a partially overlapping interplay of various signals and cell types. The different lineages and substances involved in this process display osteoinductive, osteoconductive and/or osteogenic properties (Giannoudis et al. 2007). Several strategies aiming to reproduce or boost this natural process are envisioned to enhance bone repair and restore skeletal function after critical damages. Among the methods under investigation, the use of molecules known to regulate the process of bone regeneration such as Bone Morphogenic Proteins, growth hormone, parathyroid hormone and so forth, represents an active fi eld of research (Nauth et al. 2010). Paralleling the use of bioactive molecules, the development of biomaterials used as scaffolds promoting the migration, proliferation and differentiation of bone cells is under constant progress (Ohtsuki et al. 2009). Beside these two strategies, the emergence of cell therapy as a highly promising alternative for regenerative medicine raises new hopes for the fi eld of bone regeneration. Such an approach relies on the delivery of cells, displaying osteogenic properties,to the injury sites. Several studies have shown the potential value of stem cells in repairing major injuries involving the loss of bone structure (El Tamer and Reis 2009). Mesenchymal stem cells have been identifi ed as one of the most attractive stem cell type (Jones and Yang 2011). Of importance is that mesenchymal stem cell (MSC) can give rise to osteoprogenitors that are able to differentiate into osteoblasts/osteocytes, when placed in appropriate conditions either in vitro (Mostafa et al. 2011) or in vivo (Petite et al. 2000; Quarto et al. 2001). For example, it has been demonstrated in different animal models (Arinzeh et al. 2003; Kon et al. 2000; Petite et al. 2000) but also in humans (Horwitz et al. 1999; Quarto et al. 2001) that bone marrow-derived mesenchymal stem cells (BM-MSCs) are an effective cellular product to support bone regeneration. Alternatively, other cell types such as pluripotent stem cells, umbilical cord blood-derived mesenchymal stem cells, adipose tissue-derived mesenchymal stem cells, muscle-derived stem cells and periosteal stem cells (for review see El Tamer and Reis 2009), as well as dental pulp stem cells ( Mori et al. 2011) or peripheral blood stem cells (Matsumoto et al. 2006) have the capability to differentiate into osteogenic lineages. This extending list can now be updated with a new candidate stem cell subtype, the olfactory ecto-mesenchymal stem cell (OEMSC) (Delorme et al. 2010), which is a new cellular product to consider for cell-based bone regeneration." @default.
• W2483369799 created "2016-08-23" @default.
• W2483369799 creator A5073460357 @default.
• W2483369799 creator A5080896231 @default.
• W2483369799 creator A5081903228 @default.
• W2483369799 date "2013-01-23" @default.
• W2483369799 modified "2023-09-26" @default.
• W2483369799 title "Multipotential Mesenchymal Stromal/Stem Cells in Skeletal Tissue Repair" @default.
• W2483369799 cites W1508246447 @default.
• W2483369799 cites W1535047284 @default.
• W2483369799 cites W1968442155 @default.
• W2483369799 cites W1968702093 @default.
• W2483369799 cites W1969187656 @default.
• W2483369799 cites W1973661281 @default.
• W2483369799 cites W1979782761 @default.
• W2483369799 cites W1981399912 @default.
• W2483369799 cites W1981565019 @default.
• W2483369799 cites W1981787940 @default.
• W2483369799 cites W1993314665 @default.
• W2483369799 cites W1994436843 @default.
• W2483369799 cites W1998059867 @default.
• W2483369799 cites W2010227622 @default.
• W2483369799 cites W2013895496 @default.
• W2483369799 cites W2020671207 @default.
• W2483369799 cites W2021164682 @default.
• W2483369799 cites W2021420116 @default.
• W2483369799 cites W2022346732 @default.
• W2483369799 cites W2025371271 @default.
• W2483369799 cites W2032417741 @default.
• W2483369799 cites W2034729598 @default.
• W2483369799 cites W2037362758 @default.
• W2483369799 cites W2037998434 @default.
• W2483369799 cites W2040953143 @default.
• W2483369799 cites W2054727711 @default.
• W2483369799 cites W2057071910 @default.
• W2483369799 cites W2057315313 @default.
• W2483369799 cites W2061968656 @default.
• W2483369799 cites W2070677763 @default.
• W2483369799 cites W2074624875 @default.
• W2483369799 cites W2074645659 @default.
• W2483369799 cites W2077620451 @default.
• W2483369799 cites W2078489918 @default.
• W2483369799 cites W2081595374 @default.
• W2483369799 cites W2084365441 @default.
• W2483369799 cites W2101210912 @default.
• W2483369799 cites W2105668403 @default.
• W2483369799 cites W2112453805 @default.
• W2483369799 cites W2125578520 @default.
• W2483369799 cites W2127300454 @default.
• W2483369799 cites W2132536379 @default.
• W2483369799 cites W2137744728 @default.
• W2483369799 cites W2138385394 @default.
• W2483369799 cites W2145040826 @default.
• W2483369799 cites W2154790263 @default.
• W2483369799 cites W2158430905 @default.
• W2483369799 cites W2159999899 @default.
• W2483369799 cites W2160387931 @default.
• W2483369799 cites W2165715446 @default.
• W2483369799 doi "https://doi.org/10.1201/b14590-7" @default.
• W2483369799 hasPublicationYear "2013" @default.
• W2483369799 type Work @default.
• W2483369799 sameAs 2483369799 @default.
• W2483369799 citedByCount "1" @default.
• W2483369799 countsByYear W24833697992017 @default.
• W2483369799 crossrefType "book-chapter" @default.
• W2483369799 hasAuthorship W2483369799A5073460357 @default.
• W2483369799 hasAuthorship W2483369799A5080896231 @default.
• W2483369799 hasAuthorship W2483369799A5081903228 @default.
• W2483369799 hasConcept C16930146 @default.
• W2483369799 hasConcept C198826908 @default.
• W2483369799 hasConcept C28328180 @default.
• W2483369799 hasConcept C502942594 @default.
• W2483369799 hasConcept C86803240 @default.
• W2483369799 hasConcept C95444343 @default.
• W2483369799 hasConceptScore W2483369799C16930146 @default.
• W2483369799 hasConceptScore W2483369799C198826908 @default.
• W2483369799 hasConceptScore W2483369799C28328180 @default.
• W2483369799 hasConceptScore W2483369799C502942594 @default.
• W2483369799 hasConceptScore W2483369799C86803240 @default.
• W2483369799 hasConceptScore W2483369799C95444343 @default.
• W2483369799 hasLocation W24833697991 @default.
• W2483369799 hasOpenAccess W2483369799 @default.
• W2483369799 hasPrimaryLocation W24833697991 @default.
• W2483369799 hasRelatedWork W1566942448 @default.
• W2483369799 hasRelatedWork W2106239170 @default.
• W2483369799 hasRelatedWork W2160749035 @default.
• W2483369799 hasRelatedWork W2337343130 @default.
• W2483369799 hasRelatedWork W2606223771 @default.
• W2483369799 hasRelatedWork W2904619203 @default.
• W2483369799 hasRelatedWork W3024737792 @default.
• W2483369799 hasRelatedWork W3141120103 @default.
• W2483369799 hasRelatedWork W4238146120 @default.
• W2483369799 hasRelatedWork W632441303 @default.
• W2483369799 isParatext "false" @default.
• W2483369799 isRetracted "false" @default.
• W2483369799 magId "2483369799" @default.
• W2483369799 workType "book-chapter" @default.