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- W2483444422 abstract "This chapter describes the trans-synaptic motoneuron degeneration. Trans-synaptic degeneration of motoneurons occurs following lesions of the contralateral motor cortex or emergent fibers and it affects, in an irreversible manner, approximately half the motoneuron pool. The critical time at which the degenerating motoneurons become no longer able to excite the muscle fibers is about 2 months after the upper motoneuron lesion. Although axonal sprouting is undertaken by surviving motoneurons, it may occur too late or be insufficiently vigorous to prevent some denervation atrophy of the muscle fibers from taking place. The chapter, in conclusion, highlights that whenever a population of neurons or axons has been destroyed, many of the cells to which they had projected will also undergo degeneration and the process may then be repeated at the next station in the neural pathway. A lesion may be well localized at the onset but with time its effects may be observed, functionally if not structurally, in an increasingly large part of the nervous system." @default.
- W2483444422 created "2016-08-23" @default.
- W2483444422 creator A5040896856 @default.
- W2483444422 date "1977-01-01" @default.
- W2483444422 modified "2023-09-27" @default.
- W2483444422 title "TRANS-SYNAPTIC MOTONEURONE DEGENERATION" @default.
- W2483444422 doi "https://doi.org/10.1016/b978-0-407-00058-2.50037-1" @default.
- W2483444422 hasPublicationYear "1977" @default.
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