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- W2483556529 abstract "Objective: To describe the demographics of patients with Parkinson9s Disease (PD) and comorbid Restless Limbs Syndrome (RLS) and to compare them to a large cohort of patients with primary RLS.Background: Primary RLS affects 10[percnt] of the population and is primarily inherited. Acquired RLS is comorbid with PD in up to 50[percnt] but is poorly understood. Some believe it follows the onset of motor symptoms, is more common in advanced disease, or is influenced by treatments.Methods: 78 patients with PD and RLS completed a survey addressing epidemiology, timing of symptom onset, comorbidities and family history. Results were compared to 900 patients with primary RLS.Results: In 41 (53[percnt]) PD preceded RLS and in 33 (42[percnt]) RLS was antecedent. Patients with PD were 59[percnt] female vs. 74[percnt] in primary RLS. Mean age of RLS onset was 62.5 years with PD and 40.4 without. Mean age at diagnosis of RLS was 76.7 years with PD and 53.4 in primary RLS.16 (20[percnt]) had RLS 10 or more years before PD. The remainder approximated a Gaussian distribution with 20[percnt] having RLS within 1 year of PD and only 9[percnt] more than 5 years after PD. Growing pains (28 vs 50[percnt]), Migraines (43 vs 65[percnt]) and family history of RLS (18 vs 43[percnt]) were more common in primary RLS. These rates were not significantly different in PD patients with antecedent or subsequent RLS including a subgroup analysis of patients with RLS 10 or more years before PD.Conclusions: RLS can precede the development of motor signs in PD by more than 10 years and may be a common premotor manifestation. Age at onset and presentation, and absence of migraines, growing pains and FH of RLS may help distinguish these patients from those with primary RLS. Disclosure: Dr. Dickoff has received personal compensation for activities with UCB Pharma and Teva Pharmaceuticals as a speaker. Dr. Sirkin has nothing to disclose." @default.
- W2483556529 created "2016-08-23" @default.
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- W2483556529 date "2016-04-05" @default.
- W2483556529 modified "2023-09-25" @default.
- W2483556529 title "Restless Limb Syndrome (RLS) May Precede Motor Manifestations of Parkinson Disease by More Than 10 Years: A Population Based Study (P4.319)" @default.
- W2483556529 hasPublicationYear "2016" @default.
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