Matches in SemOpenAlex for { <https://semopenalex.org/work/W248362250> ?p ?o ?g. }
Showing items 1 to 76 of
76
with 100 items per page.
- W248362250 endingPage "1835" @default.
- W248362250 startingPage "1833" @default.
- W248362250 abstract "Adult Beagles failed to respond to high concentrations of interferon (IF) when they were injected with a nuclease-resistant complex poly I:C with poly-L-lysine and carboxymethylcellulose (PICLC), by the IV or intrathecal route. An IV dose of 1 mg of PICLC/kg of body weight was lethal to 1 of 3 adult dogs, but induced IF in only 2 dogs. Smaller doses were less toxic, but also were less effective. The injection of a high dose of a known IF inducer (3 X 10(8) egg LD50 of Newcastle disease virus) also failed to induce IF in Beagles. Interferon could not be induced in vitro when primary cultures of neonatal dog lung or kidney were treated with cultures of neonatal dog lung or kidney were treated with PICLC. When these primary cell cultures were compared with the cell line Madin-Darby canine kidney in an IF assay, no difference in sensitivity to IF-induced protection from infection with vesicular stomatitis virus could be shown. This indicated that the sensitivity of the Madin-Darby cell line was not the only factor in determining the lack of IF response in dogs and indicates that the dogs are poor responders to IF induction." @default.
- W248362250 created "2016-06-24" @default.
- W248362250 creator A5009807958 @default.
- W248362250 creator A5018825347 @default.
- W248362250 creator A5090013217 @default.
- W248362250 date "1980-11-01" @default.
- W248362250 modified "2023-09-28" @default.
- W248362250 title "Minimal interferon induction in dogs, using a modified polyriboinosinic-polyribocytidylic acid complex." @default.
- W248362250 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/6163381" @default.
- W248362250 hasPublicationYear "1980" @default.
- W248362250 type Work @default.
- W248362250 sameAs 248362250 @default.
- W248362250 citedByCount "1" @default.
- W248362250 crossrefType "journal-article" @default.
- W248362250 hasAuthorship W248362250A5009807958 @default.
- W248362250 hasAuthorship W248362250A5018825347 @default.
- W248362250 hasAuthorship W248362250A5090013217 @default.
- W248362250 hasConcept C126322002 @default.
- W248362250 hasConcept C159047783 @default.
- W248362250 hasConcept C16685009 @default.
- W248362250 hasConcept C185592680 @default.
- W248362250 hasConcept C203014093 @default.
- W248362250 hasConcept C2522874641 @default.
- W248362250 hasConcept C2776178377 @default.
- W248362250 hasConcept C2777714996 @default.
- W248362250 hasConcept C2778116459 @default.
- W248362250 hasConcept C2779051857 @default.
- W248362250 hasConcept C2779057330 @default.
- W248362250 hasConcept C2780091579 @default.
- W248362250 hasConcept C71924100 @default.
- W248362250 hasConcept C86803240 @default.
- W248362250 hasConceptScore W248362250C126322002 @default.
- W248362250 hasConceptScore W248362250C159047783 @default.
- W248362250 hasConceptScore W248362250C16685009 @default.
- W248362250 hasConceptScore W248362250C185592680 @default.
- W248362250 hasConceptScore W248362250C203014093 @default.
- W248362250 hasConceptScore W248362250C2522874641 @default.
- W248362250 hasConceptScore W248362250C2776178377 @default.
- W248362250 hasConceptScore W248362250C2777714996 @default.
- W248362250 hasConceptScore W248362250C2778116459 @default.
- W248362250 hasConceptScore W248362250C2779051857 @default.
- W248362250 hasConceptScore W248362250C2779057330 @default.
- W248362250 hasConceptScore W248362250C2780091579 @default.
- W248362250 hasConceptScore W248362250C71924100 @default.
- W248362250 hasConceptScore W248362250C86803240 @default.
- W248362250 hasIssue "11" @default.
- W248362250 hasLocation W2483622501 @default.
- W248362250 hasOpenAccess W248362250 @default.
- W248362250 hasPrimaryLocation W2483622501 @default.
- W248362250 hasRelatedWork W1171681752 @default.
- W248362250 hasRelatedWork W1508862500 @default.
- W248362250 hasRelatedWork W1532291414 @default.
- W248362250 hasRelatedWork W1539606439 @default.
- W248362250 hasRelatedWork W1965836980 @default.
- W248362250 hasRelatedWork W1966968886 @default.
- W248362250 hasRelatedWork W1979741842 @default.
- W248362250 hasRelatedWork W2042946372 @default.
- W248362250 hasRelatedWork W2045642319 @default.
- W248362250 hasRelatedWork W2047254687 @default.
- W248362250 hasRelatedWork W2060541070 @default.
- W248362250 hasRelatedWork W2107674381 @default.
- W248362250 hasRelatedWork W2111253548 @default.
- W248362250 hasRelatedWork W2118899049 @default.
- W248362250 hasRelatedWork W2158098982 @default.
- W248362250 hasRelatedWork W2313199961 @default.
- W248362250 hasRelatedWork W2314757465 @default.
- W248362250 hasRelatedWork W2415153466 @default.
- W248362250 hasRelatedWork W2416653131 @default.
- W248362250 hasRelatedWork W69381180 @default.
- W248362250 hasVolume "41" @default.
- W248362250 isParatext "false" @default.
- W248362250 isRetracted "false" @default.
- W248362250 magId "248362250" @default.
- W248362250 workType "article" @default.