FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2483670341> ?p ?o ?g. }

• W2483670341 endingPage "98" @default.
• W2483670341 startingPage "92" @default.
• W2483670341 abstract "The potency of acute montelukast treatment, a leukotriene receptor antagonist, has been demonstrated as tocolytic on in vitro myometrial contractility. This study assessed the ability of a 48h montelukast treatment to modify in vitro contractions under inflammatory conditions in a pregnant rat model.Pregnant Sprague-Dawley rats were injected intraperitoneally (gestational days 20-22) with lipopolysaccharides (LPS) 200μg/kg (4 treatments at 12h intervals) alone or combined with montelukast 10mg/kg/day or a saline solution for a 48h period. Uterine rings (n=72) were obtained by median laparotomy at day 22. Spontaneous contractile activities were compared using pharmacological compounds (oxytocin, nifedipine) along with assessment of contractile parameters. Myometrial subcellular fractions were also analyzed by Western blot to quantify oxytocin, cysteinyl leukotriene receptors and inflammation markers.In in vitro experiments, the area under the curve, the amplitude and the duration of phasic contractions were significantly reduced following 48h of LPS+montelukast treatment comparatively to the LPS group. Moreover, in this same group, oxytocin (10-9-10-7M) largely decreased uterine sensitivity (p=0.04). Following LPS and montelukast treatment, the tocolytic effectiveness of nifedipine (10-9-10-7M) was increased (p<0.01). Western blot analysis confirmed the presence of type 1 CysLT receptors in all treated groups. Hence, montelukast treatment restored TNF-α and COX-2 basal levels.Our results strongly suggest that montelukast treatment could facilitate a relative uterine quiescence by decreasing its sensitivity to uterotonic agent or by increasing tocolytic efficiency under proinflammatory conditions." @default.
• W2483670341 created "2016-08-23" @default.
• W2483670341 creator A5009211936 @default.
• W2483670341 creator A5015080654 @default.
• W2483670341 creator A5015738867 @default.
• W2483670341 creator A5029848947 @default.
• W2483670341 creator A5088369949 @default.
• W2483670341 date "2016-11-01" @default.
• W2483670341 modified "2023-10-04" @default.
• W2483670341 title "Antenatal montelukast treatment reduces uterine activity associated with inflammation in a pregnant rat model" @default.
• W2483670341 cites W1512295828 @default.
• W2483670341 cites W1567571752 @default.
• W2483670341 cites W1968890803 @default.
• W2483670341 cites W1979036899 @default.
• W2483670341 cites W1994899554 @default.
• W2483670341 cites W1996546862 @default.
• W2483670341 cites W2002422193 @default.
• W2483670341 cites W2016693709 @default.
• W2483670341 cites W2019551760 @default.
• W2483670341 cites W2029282511 @default.
• W2483670341 cites W2041561300 @default.
• W2483670341 cites W2048675742 @default.
• W2483670341 cites W2051868855 @default.
• W2483670341 cites W2069822925 @default.
• W2483670341 cites W2084314623 @default.
• W2483670341 cites W2085693182 @default.
• W2483670341 cites W2088858076 @default.
• W2483670341 cites W2093953702 @default.
• W2483670341 cites W2094552994 @default.
• W2483670341 cites W2103194450 @default.
• W2483670341 cites W2103335729 @default.
• W2483670341 cites W2105812451 @default.
• W2483670341 cites W2112206762 @default.
• W2483670341 cites W2115111224 @default.
• W2483670341 cites W2117598587 @default.
• W2483670341 cites W2120812049 @default.
• W2483670341 cites W2137075680 @default.
• W2483670341 cites W2139400710 @default.
• W2483670341 cites W2152228425 @default.
• W2483670341 cites W2152246270 @default.
• W2483670341 cites W2172296213 @default.
• W2483670341 cites W2326987869 @default.
• W2483670341 doi "https://doi.org/10.1016/j.ejogrb.2016.08.003" @default.
• W2483670341 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27649459" @default.
• W2483670341 hasPublicationYear "2016" @default.
• W2483670341 type Work @default.
• W2483670341 sameAs 2483670341 @default.
• W2483670341 citedByCount "1" @default.
• W2483670341 countsByYear W24836703412022 @default.
• W2483670341 crossrefType "journal-article" @default.
• W2483670341 hasAuthorship W2483670341A5009211936 @default.
• W2483670341 hasAuthorship W2483670341A5015080654 @default.
• W2483670341 hasAuthorship W2483670341A5015738867 @default.
• W2483670341 hasAuthorship W2483670341A5029848947 @default.
• W2483670341 hasAuthorship W2483670341A5088369949 @default.
• W2483670341 hasBestOaLocation W24836703411 @default.
• W2483670341 hasConcept C126322002 @default.
• W2483670341 hasConcept C134018914 @default.
• W2483670341 hasConcept C170493617 @default.
• W2483670341 hasConcept C2776042228 @default.
• W2483670341 hasConcept C2776176026 @default.
• W2483670341 hasConcept C2776322731 @default.
• W2483670341 hasConcept C2776452501 @default.
• W2483670341 hasConcept C2776766599 @default.
• W2483670341 hasConcept C2776885963 @default.
• W2483670341 hasConcept C2777242621 @default.
• W2483670341 hasConcept C2777394947 @default.
• W2483670341 hasConcept C2778164554 @default.
• W2483670341 hasConcept C2779066055 @default.
• W2483670341 hasConcept C2779066535 @default.
• W2483670341 hasConcept C2779234561 @default.
• W2483670341 hasConcept C2780056395 @default.
• W2483670341 hasConcept C2780212800 @default.
• W2483670341 hasConcept C2780931799 @default.
• W2483670341 hasConcept C2908881489 @default.
• W2483670341 hasConcept C3019152611 @default.
• W2483670341 hasConcept C39133596 @default.
• W2483670341 hasConcept C46973012 @default.
• W2483670341 hasConcept C519063684 @default.
• W2483670341 hasConcept C54355233 @default.
• W2483670341 hasConcept C71924100 @default.
• W2483670341 hasConcept C86803240 @default.
• W2483670341 hasConceptScore W2483670341C126322002 @default.
• W2483670341 hasConceptScore W2483670341C134018914 @default.
• W2483670341 hasConceptScore W2483670341C170493617 @default.
• W2483670341 hasConceptScore W2483670341C2776042228 @default.
• W2483670341 hasConceptScore W2483670341C2776176026 @default.
• W2483670341 hasConceptScore W2483670341C2776322731 @default.
• W2483670341 hasConceptScore W2483670341C2776452501 @default.
• W2483670341 hasConceptScore W2483670341C2776766599 @default.
• W2483670341 hasConceptScore W2483670341C2776885963 @default.
• W2483670341 hasConceptScore W2483670341C2777242621 @default.
• W2483670341 hasConceptScore W2483670341C2777394947 @default.
• W2483670341 hasConceptScore W2483670341C2778164554 @default.
• W2483670341 hasConceptScore W2483670341C2779066055 @default.
• W2483670341 hasConceptScore W2483670341C2779066535 @default.
• W2483670341 hasConceptScore W2483670341C2779234561 @default.
• W2483670341 hasConceptScore W2483670341C2780056395 @default.

• next