FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2483702483> ?p ?o ?g. }

• W2483702483 endingPage "2220" @default.
• W2483702483 startingPage "2211" @default.
• W2483702483 abstract "Alterations in cardiac energy metabolism are an important contributor to the cardiac pathology associated with obesity, diabetes, and heart failure. High rates of fatty acid β-oxidation with cardiac insulin resistance represent a cardiac metabolic hallmark of diabetes and obesity, while a marginal decrease in fatty acid oxidation and a prominent decrease in insulin-stimulated glucose oxidation are commonly seen in the early stages of heart failure. Alterations in post-translational control of energy metabolic processes have recently been identified as an important contributor to these metabolic changes. In particular, lysine acetylation of non-histone proteins, which controls a diverse family of mitochondrial metabolic pathways, contributes to the cardiac energy derangements seen in obesity, diabetes, and heart failure. Lysine acetylation is controlled both via acetyltransferases and deacetylases (sirtuins), as well as by non-enzymatic lysine acetylation due to increased acetyl CoA pool size or dysregulated nicotinamide adenine dinucleotide (NAD+) metabolism (which stimulates sirtuin activity). One of the important mitochondrial acetylation targets are the fatty acid β-oxidation enzymes, which contributes to alterations in cardiac substrate preference during the course of obesity, diabetes, and heart failure, and can ultimately lead to cardiac dysfunction in these disease states. This review will summarize the role of lysine acetylation and its regulatory control in the context of mitochondrial fatty acid β-oxidation. The functional contribution of cardiac protein lysine acetylation to the shift in cardiac energy substrate preference that occurs in obesity, diabetes, and especially in the early stages of heart failure will also be reviewed. This article is part of a Special Issue entitled: The role of post-translational protein modifications on heart and vascular metabolism edited by Jason R.B. Dyck & Jan F.C. Glatz." @default.
• W2483702483 created "2016-08-23" @default.
• W2483702483 creator A5042702938 @default.
• W2483702483 creator A5061096217 @default.
• W2483702483 date "2016-12-01" @default.
• W2483702483 modified "2023-10-16" @default.
• W2483702483 title "Acetylation control of cardiac fatty acid β-oxidation and energy metabolism in obesity, diabetes, and heart failure" @default.
• W2483702483 cites W1502814520 @default.
• W2483702483 cites W1511815964 @default.
• W2483702483 cites W1553155385 @default.
• W2483702483 cites W1610508057 @default.
• W2483702483 cites W1897794632 @default.
• W2483702483 cites W1926757795 @default.
• W2483702483 cites W1955146052 @default.
• W2483702483 cites W1965935659 @default.
• W2483702483 cites W1969388950 @default.
• W2483702483 cites W1970886233 @default.
• W2483702483 cites W1972531835 @default.
• W2483702483 cites W1972616589 @default.
• W2483702483 cites W1975692560 @default.
• W2483702483 cites W1976014825 @default.
• W2483702483 cites W1978955254 @default.
• W2483702483 cites W1982164601 @default.
• W2483702483 cites W1984658022 @default.
• W2483702483 cites W1987738803 @default.
• W2483702483 cites W1990909446 @default.
• W2483702483 cites W1992913613 @default.
• W2483702483 cites W1993987541 @default.
• W2483702483 cites W1996395636 @default.
• W2483702483 cites W1997997206 @default.
• W2483702483 cites W1999697076 @default.
• W2483702483 cites W2006916011 @default.
• W2483702483 cites W2009826707 @default.
• W2483702483 cites W2011376105 @default.
• W2483702483 cites W2013841882 @default.
• W2483702483 cites W2014671368 @default.
• W2483702483 cites W2015590649 @default.
• W2483702483 cites W2017221955 @default.
• W2483702483 cites W2017225012 @default.
• W2483702483 cites W2018711046 @default.
• W2483702483 cites W2020016897 @default.
• W2483702483 cites W2023657018 @default.
• W2483702483 cites W2026859489 @default.
• W2483702483 cites W2029130907 @default.
• W2483702483 cites W2029903254 @default.
• W2483702483 cites W2030643479 @default.
• W2483702483 cites W2032934478 @default.
• W2483702483 cites W2036080646 @default.
• W2483702483 cites W2037104078 @default.
• W2483702483 cites W2037863187 @default.
• W2483702483 cites W2038011036 @default.
• W2483702483 cites W2040625305 @default.
• W2483702483 cites W2040736163 @default.
• W2483702483 cites W2048672285 @default.
• W2483702483 cites W2049065822 @default.
• W2483702483 cites W2051170391 @default.
• W2483702483 cites W2052458891 @default.
• W2483702483 cites W2052751736 @default.
• W2483702483 cites W2055397908 @default.
• W2483702483 cites W2058768220 @default.
• W2483702483 cites W2059743234 @default.
• W2483702483 cites W2059750004 @default.
• W2483702483 cites W2060300790 @default.
• W2483702483 cites W2060510261 @default.
• W2483702483 cites W2064437293 @default.
• W2483702483 cites W2067395327 @default.
• W2483702483 cites W2069262764 @default.
• W2483702483 cites W2071518542 @default.
• W2483702483 cites W2072392441 @default.
• W2483702483 cites W2073978750 @default.
• W2483702483 cites W2076619948 @default.
• W2483702483 cites W2078851955 @default.
• W2483702483 cites W2079709085 @default.
• W2483702483 cites W2080035232 @default.
• W2483702483 cites W2080655575 @default.
• W2483702483 cites W2082393205 @default.
• W2483702483 cites W2083910600 @default.
• W2483702483 cites W2084481577 @default.
• W2483702483 cites W2085578725 @default.
• W2483702483 cites W2086274343 @default.
• W2483702483 cites W2087439645 @default.
• W2483702483 cites W2087714970 @default.
• W2483702483 cites W2088714383 @default.
• W2483702483 cites W2095000965 @default.
• W2483702483 cites W2095235693 @default.
• W2483702483 cites W2096395314 @default.
• W2483702483 cites W2096772012 @default.
• W2483702483 cites W2096960190 @default.
• W2483702483 cites W2096965531 @default.
• W2483702483 cites W2098822834 @default.
• W2483702483 cites W2100899846 @default.
• W2483702483 cites W2101580126 @default.
• W2483702483 cites W2108049767 @default.
• W2483702483 cites W2114671826 @default.
• W2483702483 cites W2114815592 @default.
• W2483702483 cites W2117415612 @default.
• W2483702483 cites W2118204731 @default.
• W2483702483 cites W2118735249 @default.

• next