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- W2484000983 abstract "Objective To compare the development of Botulinum Neurotoxin (BoNT) A dose for cervical/other dystonias (TFD), blepharospasm/hemifacial spasm/Meige's syndrome (BHM), spasticity (S) and hyperhidrosis (H). Methods Open, retrospective study, performed at two medical centres with 196 patients (Universitat Gottingen: N =143, Elbe Kliniken Stade N =53). Parameters: Development of the first stable dose compared with the last follow-up dose of BoNT. The subjective efficacy of the treatment was registered with a visual analogue scale. The frequency of side effects was also monitored. Results In mean, after 23month, a stable dose was obtained. From the first treatment to the first clinically stable situation the initial dose raised by factor 1.58, from the stable dose to the last follow-up the dose was increased in mean by factor 1.16. A decline of the subjective treatment effect was not reported. In the H-subgroup, the treatment was described as increasingly effective, in mean also the duration of the treatment effect raised from 86.7 to 103.3days. 16.3% of the patients experienced short lasting side effects, of minor clinical severity. Serious adverse events did not occur. Conclusion A long-term treatment with BoNT-A is safe and keeps in general the effectivity that was reached after having achieved the stability dose. Only two patients developed a loss of effect (tachyphylaxia) and had to be changed from BoNT-A to BoNT-B." @default.
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- W2484000983 date "2016-09-01" @default.
- W2484000983 modified "2023-09-27" @default.
- W2484000983 title "EP 100. Observational study: Long-term course of Botulinum Neurotoxin (BoNT) in patients with facial or focal dystonia, spasticity and hyperhydrosis" @default.
- W2484000983 doi "https://doi.org/10.1016/j.clinph.2016.05.146" @default.
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