Matches in SemOpenAlex for { <https://semopenalex.org/work/W2484033988> ?p ?o ?g. }
- W2484033988 abstract "The adrenal cortex is critical for physiological function as the central site of glucocorticoid and mineralocorticoid synthesis. It possesses a great degree of specialized compartmentalization at multiple hierarchical levels, ranging from the tissue down to the molecular levels. In this paper, we discuss this functionalization, beginning with the tissue zonation of the adrenal cortex and how this impacts steroidogenic output. We then discuss the cellular biology of steroidogenesis, placing special emphasis on the mitochondria. Mitochondria are classically known as the powerhouses of the cell for their central role in respiratory adenosine triphosphate synthesis, and attention is given to mitochondrial electron transport, in both the context of mitochondrial respiration and mitochondrial steroid metabolism. Building on work demonstrating functional assembly of large protein complexes in respiration, we further review research demonstrating a role for multimeric protein complexes in mitochondrial cholesterol transport, steroidogenesis, and mitochondria-endoplasmic reticulum contact. We aim to highlight with this review the shift in steroidogenic cell biology from a focus on the actions of individual proteins in isolation to the actions of protein assemblies working together to execute cellular functions." @default.
- W2484033988 created "2016-08-23" @default.
- W2484033988 creator A5058801218 @default.
- W2484033988 creator A5066698171 @default.
- W2484033988 date "2016-07-29" @default.
- W2484033988 modified "2023-10-12" @default.
- W2484033988 title "Adrenal Mitochondria and Steroidogenesis: From Individual Proteins to Functional Protein Assemblies" @default.
- W2484033988 cites W1479988478 @default.
- W2484033988 cites W1493181842 @default.
- W2484033988 cites W1507135964 @default.
- W2484033988 cites W1512269360 @default.
- W2484033988 cites W1518176291 @default.
- W2484033988 cites W1519074143 @default.
- W2484033988 cites W1592609177 @default.
- W2484033988 cites W1596638623 @default.
- W2484033988 cites W1605230574 @default.
- W2484033988 cites W1748230350 @default.
- W2484033988 cites W1887098316 @default.
- W2484033988 cites W1900110634 @default.
- W2484033988 cites W1939710844 @default.
- W2484033988 cites W1964174822 @default.
- W2484033988 cites W1964888681 @default.
- W2484033988 cites W1966728800 @default.
- W2484033988 cites W1967889267 @default.
- W2484033988 cites W1969942688 @default.
- W2484033988 cites W1973821281 @default.
- W2484033988 cites W1975758830 @default.
- W2484033988 cites W1977837531 @default.
- W2484033988 cites W1979069430 @default.
- W2484033988 cites W1979225897 @default.
- W2484033988 cites W1979607551 @default.
- W2484033988 cites W1981452763 @default.
- W2484033988 cites W1982904143 @default.
- W2484033988 cites W1982926405 @default.
- W2484033988 cites W1983800969 @default.
- W2484033988 cites W1984828684 @default.
- W2484033988 cites W1986199954 @default.
- W2484033988 cites W1986248905 @default.
- W2484033988 cites W1986304241 @default.
- W2484033988 cites W1987532001 @default.
- W2484033988 cites W1987704635 @default.
- W2484033988 cites W1989351859 @default.
- W2484033988 cites W1989529321 @default.
- W2484033988 cites W1990307219 @default.
- W2484033988 cites W1991876528 @default.
- W2484033988 cites W1992741385 @default.
- W2484033988 cites W1993369409 @default.
- W2484033988 cites W1993887819 @default.
- W2484033988 cites W1993948951 @default.
- W2484033988 cites W1998206810 @default.
- W2484033988 cites W1999253411 @default.
- W2484033988 cites W2000621526 @default.
- W2484033988 cites W2002257803 @default.
- W2484033988 cites W2006849545 @default.
- W2484033988 cites W2008258993 @default.
- W2484033988 cites W2009171847 @default.
- W2484033988 cites W2009203851 @default.
- W2484033988 cites W2009364340 @default.
- W2484033988 cites W2010672712 @default.
- W2484033988 cites W2011341002 @default.
- W2484033988 cites W2011749905 @default.
- W2484033988 cites W2015536770 @default.
- W2484033988 cites W2018525366 @default.
- W2484033988 cites W2018602574 @default.
- W2484033988 cites W2020988004 @default.
- W2484033988 cites W2021467041 @default.
- W2484033988 cites W2023863611 @default.
- W2484033988 cites W2029799875 @default.
- W2484033988 cites W2031094958 @default.
- W2484033988 cites W2031116735 @default.
- W2484033988 cites W2031972450 @default.
- W2484033988 cites W2034450620 @default.
- W2484033988 cites W2035362985 @default.
- W2484033988 cites W2037612479 @default.
- W2484033988 cites W2041293636 @default.
- W2484033988 cites W2043803017 @default.
- W2484033988 cites W2045515019 @default.
- W2484033988 cites W2046353863 @default.
- W2484033988 cites W2046438084 @default.
- W2484033988 cites W2047350170 @default.
- W2484033988 cites W2048774799 @default.
- W2484033988 cites W2049338973 @default.
- W2484033988 cites W2049642674 @default.
- W2484033988 cites W2050252984 @default.
- W2484033988 cites W2052622892 @default.
- W2484033988 cites W2053497150 @default.
- W2484033988 cites W2054729369 @default.
- W2484033988 cites W2055699536 @default.
- W2484033988 cites W2057257618 @default.
- W2484033988 cites W2062452711 @default.
- W2484033988 cites W2062971730 @default.
- W2484033988 cites W2069121275 @default.
- W2484033988 cites W2070846071 @default.
- W2484033988 cites W2072595741 @default.
- W2484033988 cites W2072887098 @default.
- W2484033988 cites W2073174207 @default.
- W2484033988 cites W2073280986 @default.
- W2484033988 cites W2076994020 @default.
- W2484033988 cites W2077790055 @default.
- W2484033988 cites W2077806118 @default.