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- W2484039181 abstract "ABSTRACT monoclonal proliferation of sIg + B cells is a major feature of chronic lymphocyte leukemia. The leukemic cells were thought to be arrested at an early stage of B cell maturation. Recently it has been demonstrated that in a considerable number of cases, these leukemic cells could be induced to differentiate further in vitro . In certain cases in which a related monoclonal serum Ig band was associated with lymphocytosis, a large number of leukemic cells were induced to mature to plasma cells and to secrete a significant amount of the monoclonal Ig in vitro by the provision of allogeneic helper T cells or other mitogenic factors. The leukemic origin of the maturing cells was ascertained with anti-idiotypic antibodies to the serum Ig bands. In cases without an apparent serum Ig band, other investigators have shown that monoclonal Ig could be demonstrated in the circulation. With an appropriate concentrating procedure involving affinity chemotography a monoclonal Ig band was demonstrated in a case and an anti-idiotypic serum to the Ig band stained the neoplastic B cells of this patient. In some cases of CLL without an apparent Ig band, in vitro induction of leukemic B cells to plasma cells was possible with mitogens. The effects of phorbol ester on CLL cells were confirmed in the present studies. In a rare case of CLL with little or no membrane Ig expression by the leukemia cells, phorbol ester induced marked increase of both membrane and cytoplasmic Ig synthesis. These studies demonstrate the varied responsiveness of leukemic cells to different stimuli and suggest the heterogeneous origin of these cells. It also appears that most CLL leukemic cells are not rigidly frozen at a particular stage of maturation." @default.
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- W2484039181 date "1982-01-01" @default.
- W2484039181 modified "2023-09-26" @default.
- W2484039181 title "CHRONIC LYMPHOCYTIC LEUKEMIA: IMMUNOGLOBULIN SYNTHESIS BY LEUKEMIC B CELLS AND SOME IMPORTANT PATHOGENETIC FACTORS11This work is supported by U.S. Public Health Service Grant CA-24338." @default.
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- W2484039181 doi "https://doi.org/10.1016/b978-0-12-722380-3.50054-4" @default.
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