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• W2484056538 abstract "Publisher Summary Repeated stress produces a rise in the blood pressure of rats. This stress-induced hypertension is dependent on changes in the peripheral sympathetic system. This chapter discusses the reactions of the sympatho-adrenal system under the influence of immobilization stress. Repeated immobilization (IMO) of rats was found to bring about enhanced levels of catecholamines (CA). This conclusion was supported by the increased levels of adrenal, plasma, and urinary CA, by increased biosynthesis of adrenal CA, measured in vivo after administration of labeled precursors, and by increases in the activity of adrenal catecholamine-synthesizing enzymes tyrosine hydroxylase (TH), dopamine-β-hydroxylase (DBH), and phenylethanolamine-N-methyltransferase (PNMT). Increased CA levels in the organism of repeatedly IMO rats might not only be because of enhanced CA synthesis but to diminished CA degradation as well. It has been found that stress affects a significant decrease of catechol-O-methyltransferase (COMT) activity in the liver of rats, which is related to the inhibitory effect of corticosterone (B), which under stress is increased in the plasma of these rats. The inhibitory effect of corticosteroids on liver COMT activity has been established in vitro on liver explants in tissue culture." @default.
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• W2484056538 date "1976-01-01" @default.
• W2484056538 modified "2023-10-15" @default.
• W2484056538 title "EFFECT OF STRESS ON CATECHOLAMINE SYNTHESIZING AND DEGRADING ENZYMES IN CONTROL AND SPONTANEOUSLY HYPERTENSIVE RATS11Supported in part by The Foundation's Fund for Research in Psychiatry, New Haven, Conn., USA, Research Grant Number G 71 – 498." @default.
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• W2484056538 doi "https://doi.org/10.1016/b978-0-08-020588-5.50037-0" @default.
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