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- W2484093582 abstract "This editorial refers to ‘Randomized comparison of intravenous procainamide vs. intravenous amiodarone for the acute treatment of tolerated wide QRS tachycardia: the PROCAMIO study’, by M. Ortiz et al ., doi:10.1093/eurheartj/ehw230 Clinical guidelines often make recommendations based on the consensus of the authors alone, with little supporting evidence. An area of medicine where it is very difficult to perform clinical trials is in the setting of emergency treatment of cardiac arrhythmia. As a result, there are few data informing us of the optimal strategy for the drug management of haemodynamically tolerated ventricular tachycardia (VT). Current guidelines acknowledge the potential advantages of pharmacological cardioversion, which may avoid the logistical issues of organizing an anaesthetic with the necessary additional staff.1When considering pharmacological cardioversion, reasonable choices of agent include i.v. beta-blockers (e.g. metoprolol), class I agents (e.g. procainamide and lignocaine), a class III agent (e.g. sotalol), or amiodarone with mixed ion channel and beta-blocking action. To date, the complement of randomized controlled trials comparing these drugs is limited, though lignocaine appears to be the least effective,2 and current European guidelines advise either procainamide or amiodarone, with an emphasis on amiodarone use in …" @default.
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- W2484093582 date "2016-07-28" @default.
- W2484093582 modified "2023-09-25" @default.
- W2484093582 title "A dolus of i.v. amiodarone" @default.
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- W2484093582 doi "https://doi.org/10.1093/eurheartj/ehw327" @default.
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