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- W2484121982 abstract "The thyroid gland is the organ that is most prominently affected by a lack of regular intake of iodine, a trace mineral, key nutritional factor and indispensable chemical component of thyroid hormones. Because thyroid hormones are essential for the human body, iodine deficiency can cause considerable deviation from normal physical and mental development, including growth. It is the major cause of thyroid enlargement or goiter, which in part is a maladaptation to iodine deficiency. Increased oxidative attack is also detectable in the form of modified DNA, which could lead to mutations. These mutations are the prerequisite for development of thyroid nodules, which are predominantly benign thyroid tumors, but could also constitute malignant lesions. Although also detectable in the normal thyroid gland the oxidative burden linked to hormone synthesis and H2O2 production is exaggerated by lack of iodine in the diet. This in turn causes a higher frequency of thyroid tumors in iodine-deficient regions. Despite being predominantly benign tumors, the risk of malignancy is a frequent diagnostic issue. Moreover, the current medical treatment options for benign nodules are of limited efficiency. Therefore, understanding the molecular etiology of thyroid tumors and the main factors that cause them is an ongoing issue in endocrinological research." @default.
- W2484121982 created "2016-08-23" @default.
- W2484121982 creator A5007617070 @default.
- W2484121982 creator A5022024157 @default.
- W2484121982 date "2009-01-01" @default.
- W2484121982 modified "2023-09-25" @default.
- W2484121982 title "Iodine Deficiency, Antioxidant Response and Mutagenesis in the Thyroid Gland" @default.
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- W2484121982 doi "https://doi.org/10.1016/b978-0-12-374135-6.00057-1" @default.
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