FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2484168144> ?p ?o ?g. }

• W2484168144 endingPage "54951" @default.
• W2484168144 startingPage "54937" @default.
• W2484168144 abstract "Amplification of the MYCN oncogene, a member of the MYC family of transcriptional regulators, is one of the most powerful prognostic markers identified for poor outcome in neuroblastoma, the most common extracranial solid cancer in childhood. While MYCN has been established as a key driver of malignancy in neuroblastoma, the underlying molecular mechanisms are poorly understood. Transcription factor activating enhancer binding protein-4 (TFAP4) has been reported to be a direct transcriptional target of MYC. We show for the first time that high expression of TFAP4 in primary neuroblastoma patients is associated with poor clinical outcome. siRNA-mediated suppression of TFAP4 in MYCN-expressing neuroblastoma cells led to inhibition of cell proliferation and migration. Chromatin immunoprecipitation assay demonstrated that TFAP4 expression is positively regulated by MYCN. Microarray analysis identified genes regulated by both MYCN and TFAP4 in neuroblastoma cells, including Phosphoribosyl-pyrophosphate synthetase-2 (PRPS2) and Syndecan-1 (SDC1), which are involved in cancer cell proliferation and metastasis. Overall this study suggests a regulatory circuit in which MYCN by elevating TFAP4 expression, cooperates with it to control a specific set of genes involved in tumor progression. These findings highlight the existence of a MYCN-TFAP4 axis in MYCN-driven neuroblastoma as well as identifying potential therapeutic targets for aggressive forms of this disease." @default.
• W2484168144 created "2016-08-23" @default.
• W2484168144 creator A5003639088 @default.
• W2484168144 creator A5009084764 @default.
• W2484168144 creator A5011765291 @default.
• W2484168144 creator A5013270397 @default.
• W2484168144 creator A5013297039 @default.
• W2484168144 creator A5014528965 @default.
• W2484168144 creator A5022993204 @default.
• W2484168144 creator A5025704120 @default.
• W2484168144 creator A5051196420 @default.
• W2484168144 creator A5067013871 @default.
• W2484168144 creator A5072009574 @default.
• W2484168144 creator A5078090612 @default.
• W2484168144 creator A5078723889 @default.
• W2484168144 creator A5082360687 @default.
• W2484168144 creator A5085808208 @default.
• W2484168144 creator A5088511308 @default.
• W2484168144 date "2016-07-19" @default.
• W2484168144 modified "2023-10-18" @default.
• W2484168144 title "MYCN promotes neuroblastoma malignancy by establishing a regulatory circuit with transcription factor AP4" @default.
• W2484168144 cites W129198147 @default.
• W2484168144 cites W1490872766 @default.
• W2484168144 cites W1560804587 @default.
• W2484168144 cites W1964847767 @default.
• W2484168144 cites W1967098715 @default.
• W2484168144 cites W1980717479 @default.
• W2484168144 cites W1990099735 @default.
• W2484168144 cites W1991402389 @default.
• W2484168144 cites W2021536610 @default.
• W2484168144 cites W2026807251 @default.
• W2484168144 cites W2029106426 @default.
• W2484168144 cites W2048915877 @default.
• W2484168144 cites W2052864542 @default.
• W2484168144 cites W2058390366 @default.
• W2484168144 cites W2058577321 @default.
• W2484168144 cites W2061917886 @default.
• W2484168144 cites W2061971383 @default.
• W2484168144 cites W2068010171 @default.
• W2484168144 cites W2070058781 @default.
• W2484168144 cites W2073120856 @default.
• W2484168144 cites W2077462602 @default.
• W2484168144 cites W2079458256 @default.
• W2484168144 cites W2079750277 @default.
• W2484168144 cites W2082418977 @default.
• W2484168144 cites W2087539641 @default.
• W2484168144 cites W2089660847 @default.
• W2484168144 cites W2096797981 @default.
• W2484168144 cites W2098282574 @default.
• W2484168144 cites W2101042741 @default.
• W2484168144 cites W2101949381 @default.
• W2484168144 cites W2104368170 @default.
• W2484168144 cites W2106964107 @default.
• W2484168144 cites W2107800068 @default.
• W2484168144 cites W2123964155 @default.
• W2484168144 cites W2130925781 @default.
• W2484168144 cites W2132570017 @default.
• W2484168144 cites W2133764144 @default.
• W2484168144 cites W2135103035 @default.
• W2484168144 cites W2138809862 @default.
• W2484168144 cites W2138929006 @default.
• W2484168144 cites W2140956142 @default.
• W2484168144 cites W2144566858 @default.
• W2484168144 cites W2145757445 @default.
• W2484168144 cites W2146613018 @default.
• W2484168144 cites W2150436360 @default.
• W2484168144 cites W2156683768 @default.
• W2484168144 cites W2157364449 @default.
• W2484168144 cites W2164995293 @default.
• W2484168144 cites W2325149713 @default.
• W2484168144 cites W2401384141 @default.
• W2484168144 cites W2406511268 @default.
• W2484168144 cites W47603266 @default.
• W2484168144 doi "https://doi.org/10.18632/oncotarget.10709" @default.
• W2484168144 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5342392" @default.
• W2484168144 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27448979" @default.
• W2484168144 hasPublicationYear "2016" @default.
• W2484168144 type Work @default.
• W2484168144 sameAs 2484168144 @default.
• W2484168144 citedByCount "19" @default.
• W2484168144 countsByYear W24841681442017 @default.
• W2484168144 countsByYear W24841681442018 @default.
• W2484168144 countsByYear W24841681442019 @default.
• W2484168144 countsByYear W24841681442020 @default.
• W2484168144 countsByYear W24841681442021 @default.
• W2484168144 countsByYear W24841681442022 @default.
• W2484168144 countsByYear W24841681442023 @default.
• W2484168144 crossrefType "journal-article" @default.
• W2484168144 hasAuthorship W2484168144A5003639088 @default.
• W2484168144 hasAuthorship W2484168144A5009084764 @default.
• W2484168144 hasAuthorship W2484168144A5011765291 @default.
• W2484168144 hasAuthorship W2484168144A5013270397 @default.
• W2484168144 hasAuthorship W2484168144A5013297039 @default.
• W2484168144 hasAuthorship W2484168144A5014528965 @default.
• W2484168144 hasAuthorship W2484168144A5022993204 @default.
• W2484168144 hasAuthorship W2484168144A5025704120 @default.
• W2484168144 hasAuthorship W2484168144A5051196420 @default.
• W2484168144 hasAuthorship W2484168144A5067013871 @default.

• next