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• W2484236462 abstract "Abstract Magnetic resonance imaging (MRI) provides the unique ability to study metabolic and microvasculature functions in skeletal muscle using phosphorus and proton measurements. However, the low sensitivity of these techniques can make it difficult to capture dynamic muscle activity due to the temporal resolution required for kinetic measurements during and after exercise tasks. Here, we report the design of a dual-nuclei coil array that enables proton and phosphorus MRI of the human lower extremities with high spatial and temporal resolution. We developed an array with whole-volume coverage of the calf and a phosphorus signal-to-noise ratio of more than double that of a birdcage coil in the gastrocnemius muscles. This enabled the local assessment of phosphocreatine recovery kinetics following a plantar flexion exercise using an efficient sampling scheme with a 6 s temporal resolution. The integrated proton array demonstrated image quality approximately equal to that of a clinical state-of-the-art knee coil, which enabled fat quantification and dynamic blood oxygen level-dependent measurements that reflect microvasculature function. The developed array and time-efficient pulse sequences were combined to create a localized assessment of calf metabolism using phosphorus measurements and vasculature function using proton measurements, which could provide new insights into muscle function." @default.
• W2484236462 created "2016-08-23" @default.
• W2484236462 creator A5032042922 @default.
• W2484236462 creator A5046671986 @default.
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• W2484236462 date "2016-07-28" @default.
• W2484236462 modified "2023-09-29" @default.
• W2484236462 title "Magnetic Resonance Imaging of Phosphocreatine and Determination of BOLD Kinetics in Lower Extremity Muscles using a Dual-Frequency Coil Array" @default.
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• W2484236462 doi "https://doi.org/10.1038/srep30568" @default.
• W2484236462 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4964597" @default.
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• W2484236462 hasPublicationYear "2016" @default.
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