FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2484301708> ?p ?o ?g. }

• W2484301708 abstract "Metabolic impairment is an important contributor to heart failure (HF) pathogenesis and progression. Dysregulated metabolic pathways remain poorly characterized in patients with HF and preserved ejection fraction (HFpEF). We sought to determine metabolic abnormalities in HFpEF and identify pathways differentially altered in HFpEF versus HF with reduced ejection fraction (HFrEF).We identified HFpEF cases, HFrEF controls, and no-HF controls from the CATHGEN study of sequential patients undergoing cardiac catheterization. HFpEF cases (N=282) were defined by left ventricular ejection fraction (LVEF) ≥45%, diastolic dysfunction grade ≥1, and history of HF; HFrEF controls (N=279) were defined similarly, except for having LVEF <45%. No-HF controls (N=191) had LVEF ≥45%, normal diastolic function, and no HF diagnosis. Targeted mass spectrometry and enzymatic assays were used to quantify 63 metabolites in fasting plasma. Principal components analysis reduced the 63 metabolites to uncorrelated factors, which were compared across groups using ANCOVA. In basic and fully adjusted models, long-chain acylcarnitine factor levels differed significantly across groups (P<0.0001) and were greater in HFrEF than HFpEF (P=0.0004), both of which were greater than no-HF controls. We confirmed these findings in sensitivity analyses using stricter inclusion criteria, alternative LVEF thresholds, and adjustment for insulin resistance.We identified novel circulating metabolites reflecting impaired or dysregulated fatty acid oxidation that are independently associated with HF and differentially elevated in HFpEF and HFrEF. These results elucidate a specific metabolic pathway in HF and suggest a shared metabolic mechanism in HF along the LVEF spectrum." @default.
• W2484301708 created "2016-08-23" @default.
• W2484301708 creator A5003320815 @default.
• W2484301708 creator A5006213707 @default.
• W2484301708 creator A5012849300 @default.
• W2484301708 creator A5017226394 @default.
• W2484301708 creator A5021832589 @default.
• W2484301708 creator A5022076272 @default.
• W2484301708 creator A5022951863 @default.
• W2484301708 creator A5029499930 @default.
• W2484301708 creator A5036509904 @default.
• W2484301708 creator A5037532091 @default.
• W2484301708 creator A5043091584 @default.
• W2484301708 creator A5049799218 @default.
• W2484301708 creator A5054385513 @default.
• W2484301708 creator A5055488258 @default.
• W2484301708 creator A5059482726 @default.
• W2484301708 creator A5062992566 @default.
• W2484301708 date "2016-08-08" @default.
• W2484301708 modified "2023-10-13" @default.
• W2484301708 title "Metabolomic Profiling Identifies Novel Circulating Biomarkers of Mitochondrial Dysfunction Differentially Elevated in Heart Failure With Preserved Versus Reduced Ejection Fraction: Evidence for Shared Metabolic Impairments in Clinical Heart Failure" @default.
• W2484301708 cites W1129605249 @default.
• W2484301708 cites W157502360 @default.
• W2484301708 cites W1583066327 @default.
• W2484301708 cites W1607125482 @default.
• W2484301708 cites W164205712 @default.
• W2484301708 cites W1767035094 @default.
• W2484301708 cites W1826176937 @default.
• W2484301708 cites W1890886324 @default.
• W2484301708 cites W1927803805 @default.
• W2484301708 cites W1968853872 @default.
• W2484301708 cites W1970278991 @default.
• W2484301708 cites W1974438296 @default.
• W2484301708 cites W1980544438 @default.
• W2484301708 cites W1982403431 @default.
• W2484301708 cites W1982509198 @default.
• W2484301708 cites W1984875752 @default.
• W2484301708 cites W1992644002 @default.
• W2484301708 cites W1995392322 @default.
• W2484301708 cites W1997071795 @default.
• W2484301708 cites W1997320786 @default.
• W2484301708 cites W2001644420 @default.
• W2484301708 cites W2002094413 @default.
• W2484301708 cites W2004191609 @default.
• W2484301708 cites W2012748167 @default.
• W2484301708 cites W2014671368 @default.
• W2484301708 cites W2015080774 @default.
• W2484301708 cites W2016433470 @default.
• W2484301708 cites W2022217710 @default.
• W2484301708 cites W2024354971 @default.
• W2484301708 cites W2024686537 @default.
• W2484301708 cites W2028068170 @default.
• W2484301708 cites W2028274725 @default.
• W2484301708 cites W2028621708 @default.
• W2484301708 cites W2029163015 @default.
• W2484301708 cites W2029590799 @default.
• W2484301708 cites W2030760725 @default.
• W2484301708 cites W2030800549 @default.
• W2484301708 cites W2037136746 @default.
• W2484301708 cites W2050673830 @default.
• W2484301708 cites W2054822403 @default.
• W2484301708 cites W2057047340 @default.
• W2484301708 cites W2064612269 @default.
• W2484301708 cites W2067601183 @default.
• W2484301708 cites W2068519950 @default.
• W2484301708 cites W2071518542 @default.
• W2484301708 cites W2071589440 @default.
• W2484301708 cites W2080706636 @default.
• W2484301708 cites W2091949266 @default.
• W2484301708 cites W2096189508 @default.
• W2484301708 cites W2098605555 @default.
• W2484301708 cites W2098635886 @default.
• W2484301708 cites W2098641028 @default.
• W2484301708 cites W2099783126 @default.
• W2484301708 cites W2101914549 @default.
• W2484301708 cites W2108790161 @default.
• W2484301708 cites W2119340816 @default.
• W2484301708 cites W2122367003 @default.
• W2484301708 cites W2123452207 @default.
• W2484301708 cites W2125593259 @default.
• W2484301708 cites W2126830306 @default.
• W2484301708 cites W2127039247 @default.
• W2484301708 cites W2132339674 @default.
• W2484301708 cites W2137784332 @default.
• W2484301708 cites W2143094666 @default.
• W2484301708 cites W2144430260 @default.
• W2484301708 cites W2148910374 @default.
• W2484301708 cites W2150012913 @default.
• W2484301708 cites W2152072062 @default.
• W2484301708 cites W2153819921 @default.
• W2484301708 cites W2155559652 @default.
• W2484301708 cites W2157104859 @default.
• W2484301708 cites W2160172778 @default.
• W2484301708 cites W2166504467 @default.
• W2484301708 cites W2167039546 @default.
• W2484301708 cites W2167779832 @default.
• W2484301708 cites W2278098643 @default.
• W2484301708 cites W2475261460 @default.
• W2484301708 cites W2517235140 @default.
• W2484301708 cites W2527933700 @default.

• next