Matches in SemOpenAlex for { <https://semopenalex.org/work/W2484342387> ?p ?o ?g. }
Showing items 1 to 70 of
70
with 100 items per page.
- W2484342387 abstract "Background: Erythropoietin (EPO) is a glycoprotein hormone member of the type 1 cytokine super family that is produced by renal cortical and outer medullary type 1 fibroblasts in response to tissue hypoxia. It has a hematopoietic function, but recent studies have shown that EPO has several non hematopoietic functions. EPO limits the destructive potential of tumor necrosis factor α and other proinflammatory cytokines in different tissues. Objective: Studying the possible protective and curative effects of EPO on diabetes in alloxan-induced diabetic rats. Material and methods: Fifty adult male albino rats of local strain between 7-8 weeks old and weighing 140-160 g were used. The rats were divided into 5 equal groups. Group I (control group), Group II (erythropoietin- treated group), Group III (diabetic group), Group IV (EPO- pretreated diabetic group), and group V (EPO-treated diabetic group). The body weight, food consumption, blood glucose level, serum tumor necrosis factor α (TNF-α) and serum interleukin 6 (IL-6) were determined for all groups. Results: Blood glucose level, serum tumor necrosis factor α (TNF-α) and serum interleukin 6 (IL-6) decreased in EPO-pretreated and treated diabetic groups when compared to the diabetic rats. These results were confirmed by the histopathological study which showed marked improvement of the destructive effect on pancreatic islet cells induced by alloxan especially when EPO treatment was given after two weeks of alloxan injection. Conclusion: EPO is a general tissue protective cytokine. It acts on glucose metabolism and increasing β cell mass. Thus, promotion of EPO signaling in β cells may be a novel therapeutic strategy for diabetes prevention and treatment." @default.
- W2484342387 created "2016-08-23" @default.
- W2484342387 creator A5004672494 @default.
- W2484342387 creator A5064764605 @default.
- W2484342387 creator A5078071901 @default.
- W2484342387 creator A5081431744 @default.
- W2484342387 creator A5091842137 @default.
- W2484342387 date "2015-07-01" @default.
- W2484342387 modified "2023-09-27" @default.
- W2484342387 title "THE POTENTIAL PROTECTIVE AND CURATIVE EFFECTS OF ERYTHROPOIETIN ON DIABETIC MALE RATS" @default.
- W2484342387 doi "https://doi.org/10.12816/0018610" @default.
- W2484342387 hasPublicationYear "2015" @default.
- W2484342387 type Work @default.
- W2484342387 sameAs 2484342387 @default.
- W2484342387 citedByCount "0" @default.
- W2484342387 crossrefType "journal-article" @default.
- W2484342387 hasAuthorship W2484342387A5004672494 @default.
- W2484342387 hasAuthorship W2484342387A5064764605 @default.
- W2484342387 hasAuthorship W2484342387A5078071901 @default.
- W2484342387 hasAuthorship W2484342387A5081431744 @default.
- W2484342387 hasAuthorship W2484342387A5091842137 @default.
- W2484342387 hasConcept C126322002 @default.
- W2484342387 hasConcept C134018914 @default.
- W2484342387 hasConcept C164027704 @default.
- W2484342387 hasConcept C17991360 @default.
- W2484342387 hasConcept C2776914184 @default.
- W2484342387 hasConcept C2778248108 @default.
- W2484342387 hasConcept C2778534260 @default.
- W2484342387 hasConcept C2778690821 @default.
- W2484342387 hasConcept C2779703530 @default.
- W2484342387 hasConcept C555293320 @default.
- W2484342387 hasConcept C71924100 @default.
- W2484342387 hasConceptScore W2484342387C126322002 @default.
- W2484342387 hasConceptScore W2484342387C134018914 @default.
- W2484342387 hasConceptScore W2484342387C164027704 @default.
- W2484342387 hasConceptScore W2484342387C17991360 @default.
- W2484342387 hasConceptScore W2484342387C2776914184 @default.
- W2484342387 hasConceptScore W2484342387C2778248108 @default.
- W2484342387 hasConceptScore W2484342387C2778534260 @default.
- W2484342387 hasConceptScore W2484342387C2778690821 @default.
- W2484342387 hasConceptScore W2484342387C2779703530 @default.
- W2484342387 hasConceptScore W2484342387C555293320 @default.
- W2484342387 hasConceptScore W2484342387C71924100 @default.
- W2484342387 hasLocation W24843423871 @default.
- W2484342387 hasOpenAccess W2484342387 @default.
- W2484342387 hasPrimaryLocation W24843423871 @default.
- W2484342387 hasRelatedWork W133214591 @default.
- W2484342387 hasRelatedWork W1980093324 @default.
- W2484342387 hasRelatedWork W1982751354 @default.
- W2484342387 hasRelatedWork W2017838698 @default.
- W2484342387 hasRelatedWork W2087539319 @default.
- W2484342387 hasRelatedWork W2325679810 @default.
- W2484342387 hasRelatedWork W2344564867 @default.
- W2484342387 hasRelatedWork W2368730155 @default.
- W2484342387 hasRelatedWork W2376193788 @default.
- W2484342387 hasRelatedWork W2391127814 @default.
- W2484342387 hasRelatedWork W2606223985 @default.
- W2484342387 hasRelatedWork W2736569586 @default.
- W2484342387 hasRelatedWork W2760697813 @default.
- W2484342387 hasRelatedWork W2800748798 @default.
- W2484342387 hasRelatedWork W2802293464 @default.
- W2484342387 hasRelatedWork W2810601056 @default.
- W2484342387 hasRelatedWork W2973167336 @default.
- W2484342387 hasRelatedWork W2996018803 @default.
- W2484342387 hasRelatedWork W3007054731 @default.
- W2484342387 hasRelatedWork W3025506802 @default.
- W2484342387 isParatext "false" @default.
- W2484342387 isRetracted "false" @default.
- W2484342387 magId "2484342387" @default.
- W2484342387 workType "article" @default.