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• W2484396837 abstract "Publisher Summary This chapter reviews genetic and selection methodology that is currently utilized in the selection, purification, and stabilization of high-productivity mutants as exemplified by currently important fermentation microorganisms. Microbial culture selection is involved in the initial isolation of microorganisms from nature and later in the purification of strains of interest because of the synthesis of desirable metabolic products. In most large-scale screening programs, rare, unusual cultures are selected by taxonomists as the probability of new interesting activities is maximized in sensitive specific assays using rare, fastidious microorganisms. The purification of unusual organisms is difficult and involves considerable technique in culture selection. Also, pure cultures of microorganisms are inherently variable in their growth characteristics and metabolic activities. Although natural selection and mutation selection are generally successful in improving titers of the above metabolites, culture stability, growth and sporulation characteristics often represent additional critical problems to be resolved. These characteristics are also inherent genetic problems and must be resolved in a culture improvement program. The elimination or decrease in titers of unwanted components can be resolved by culture selection or by changes in the chemical and physical environment of fermentation. Thereafter, a high-producing stable strain is essential both to fundamental studies carried out to establish pathways of biosynthesis and to fermentation optimization through control of the chemical and physical environments." @default.
• W2484396837 created "2016-08-23" @default.
• W2484396837 creator A5018741594 @default.
• W2484396837 creator A5044437725 @default.
• W2484396837 date "1979-01-01" @default.
• W2484396837 modified "2023-09-23" @default.
• W2484396837 title "Microbial Culture Selection" @default.
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