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- W2484451097 abstract "The incidence and mortality rates of prostate cancer are significantly higher in African-American men than European-American men. The causes of this cancer health disparity remain to be fully elucidated. We previously tested the hypothesis that differences in tumor biology contribute to the survival health disparity associated with prostate cancer. Using microarray technology, we compared gene expression profiles of primary prostate tumors resected from 33 African-American and 36 European-American patients. Our initial analysis revealed 162 transcripts to be differentially expressed between the two ethnic groups at a false discovery rate of 5% or less. Using Predication Analysis of Microarray (PAM) we identified a two-gene signature that accurately differentiated between African-American and European-American patients. These two genes were phosphoserine phosphatase homologue (PSPHL) and crystalline β-B2 (CRYBB2). Very little is known about the functions of these genes, however PSPHL is located on chromosome 7q11.2; a region known to have gain of function related to advanced tumor stage in prostate cancer. The ability of the two-gene signature to distinguish between these two patient groups was confirmed in an independent prostate cancer validation set and also in a study of breast cancer. Quantitiative RT-PCR analysis revealed PSPHL to be highly expressed in tumor tissues from African-American patients, when compared to European-American patients. Additionally, PSPHL expression was significantly higher expressed in prostate tumor tissues when compared to surrounding non-tumor tissues, suggesting that PSPHL is not merely a marker of race/ethnicity but may additionally function as a cancer susceptibility gene. Using targeted siRNA technology and a yeast two-hybrid screen, we recently identified a number of genes and pathways that may be related to PSPHL function. In conclusion, the unique expression of PSPHL in prostate tumors suggests that it may function as a prostate cancer susceptibility gene." @default.
- W2484451097 created "2016-08-23" @default.
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- W2484451097 date "2009-02-01" @default.
- W2484451097 modified "2023-09-23" @default.
- W2484451097 title "Abstract PR-1: Identification of a novel candidate prostate cancer susceptibility gene, phosphoserine phosphatase homologue, in African American men" @default.
- W2484451097 hasPublicationYear "2009" @default.
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