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- W2484516892 endingPage "885.e6" @default.
- W2484516892 startingPage "876" @default.
- W2484516892 abstract "Numerous drugs can cause pulmonary reactions in children. Chemotherapeutic agents are most frequently implicated, although toxic effects of other medications have been recognized. Reactions to chemotherapeutic agents may be dose-related; most reactions to noncytotoxic agents develop idiosyncratically. Clinical/pathologic syndromes described include diffuse interstitial pneumonitis and fibrosis, hypersensitivity pneumonitis, noncardiogenic pulmonary edema, pleural effusion, bronchiolitis obliterans, and alveolar hemorrhage. Presenting symptoms vary but often include fever, cough, and dyspnea, and radiologic studies demonstrate diffuse alveolar and/or interstitial abnormalities. Abnormalities in lung function may precede symptoms and radiographic changes. Patterns of abnormalities on chest CT, bronchoalveolar fluid analysis and cultures, and lung histopathology may be useful in categorizing and defining extent of disease but may be nonspecific. Other disorders, including infection, hemorrhage, lung disease related to underlying disease, and radiation damage, must be considered. Criteria for the diagnosis of drug-induced lung disease have been outlined. Although some drug-induced lung injury is reversible, persistent and even fatal dysfunction may occur. Survivors of childhood cancer require follow-up as lung disease may develop remotely from drug exposure and be progressive. More precise information about risk factors, including genetic predisposition and mechanisms of injury, along with more sensitive diagnostic and monitoring approaches are needed for development of improved therapeutic strategies, including early intervention." @default.
- W2484516892 created "2016-08-23" @default.
- W2484516892 creator A5034834495 @default.
- W2484516892 creator A5079181789 @default.
- W2484516892 date "2019-01-01" @default.
- W2484516892 modified "2023-10-17" @default.
- W2484516892 title "Lung Injury Caused by Pharmacologic Agents" @default.
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