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- W2484792144 abstract "In vitro and in vivo studies reported the anti-cancer potential of organosulfur compounds (OSCs) as they trigger biological effects leading to cell cycle arrest with accumulation of cells in G2/M, alteration of the microtubular network, modulation of Bcl-2 family protein expression patterns and changes of the redox status. Despite these well-described effects, no OSC derivative is yet undergoing clinical trials even though their chemistry is well understood as OSCs act as hydrogen sulfide (H2S) donors. H2S is a biological mediator, synthesized through cysteine degradation and modulates vasodilation, cytoprotection, inflammation and angiogenesis. It is well accepted that H2S plays a biphasic pharmacological role: the inhibition of endogenous synthesis of H2S and paradoxically also the use of H2S donors to increase H2S concentration, induce both anti-cancer effects leading therefore to controversial discussions. Altogether, the role of H2S in the anti-cancer action of OSCs remains poorly understood. In this review, we hypothesize that OSCs act through H2S signaling pathways in cancer cells, and that a clearer understanding of the mechanism of action of H2S in OSC-mediated anti-cancer activity is required for further application of these compounds in translational medicine." @default.
- W2484792144 created "2016-08-23" @default.
- W2484792144 creator A5018593253 @default.
- W2484792144 creator A5027375056 @default.
- W2484792144 creator A5067297017 @default.
- W2484792144 creator A5089909449 @default.
- W2484792144 date "2016-09-01" @default.
- W2484792144 modified "2023-10-01" @default.
- W2484792144 title "Garlic-derived natural polysulfanes as hydrogen sulfide donors: Friend or foe?" @default.
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