FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2484812056> ?p ?o ?g. }

• W2484812056 endingPage "62" @default.
• W2484812056 startingPage "955" @default.
• W2484812056 abstract "Although numerous children receive methylphenidate hydrochloride for the treatment of attention-deficit/hyperactivity disorder (ADHD), little is known about age-dependent and possibly lasting effects of methylphenidate on the human dopaminergic system.To determine whether the effects of methylphenidate on the dopaminergic system are modified by age and to test the hypothesis that methylphenidate treatment of young but not adult patients with ADHD induces lasting effects on the cerebral blood flow response to dopamine challenge, a noninvasive probe for dopamine function.A randomized, double-blind, placebo-controlled trial (Effects of Psychotropic Drugs on Developing Brain-Methylphenidate) among ADHD referral centers in the greater Amsterdam area in the Netherlands between June 1, 2011, and June 15, 2015. Additional inclusion criteria were male sex, age 10 to 12 years or 23 to 40 years, and stimulant treatment-naive status.Treatment with either methylphenidate or a matched placebo for 16 weeks.Change in the cerebral blood flow response to an acute challenge with methylphenidate, noninvasively assessed using pharmacological magnetic resonance imaging, between baseline and 1 week after treatment. Data were analyzed using intent-to-treat analyses.Among 131 individuals screened for eligibility, 99 patients met DSM-IV criteria for ADHD, and 50 participants were randomized to receive methylphenidate and 49 to placebo. Sixteen weeks of methylphenidate treatment increased the cerebral blood flow response to methylphenidate within the thalamus (mean difference, 6.5; 95% CI, 0.4-12.6; P = .04) of children aged 10 to 12 years old but not in adults or in the placebo group. In the striatum, the methylphenidate condition differed significantly from placebo in children but not in adults (mean difference, 7.7; 95% CI, 0.7-14.8; P = .03).We confirm preclinical data and demonstrate age-dependent effects of methylphenidate treatment on human extracellular dopamine striatal-thalamic circuitry. Given its societal relevance, these data warrant replication in larger groups with longer follow-up.identifier: NL34509.000.10 and trialregister.nl identifier: NTR3103." @default.
• W2484812056 created "2016-08-23" @default.
• W2484812056 creator A5000061600 @default.
• W2484812056 creator A5000501122 @default.
• W2484812056 creator A5004468255 @default.
• W2484812056 creator A5010718326 @default.
• W2484812056 creator A5012854700 @default.
• W2484812056 creator A5016425494 @default.
• W2484812056 creator A5019104236 @default.
• W2484812056 creator A5021284732 @default.
• W2484812056 creator A5026207242 @default.
• W2484812056 creator A5040266732 @default.
• W2484812056 creator A5042337330 @default.
• W2484812056 creator A5046908675 @default.
• W2484812056 creator A5051056050 @default.
• W2484812056 creator A5052901925 @default.
• W2484812056 creator A5053874473 @default.
• W2484812056 creator A5068855118 @default.
• W2484812056 creator A5077534388 @default.
• W2484812056 creator A5085153302 @default.
• W2484812056 date "2016-09-01" @default.
• W2484812056 modified "2023-10-13" @default.
• W2484812056 title "Age-Dependent Effects of Methylphenidate on the Human Dopaminergic System in Young vs Adult Patients With Attention-Deficit/Hyperactivity Disorder: A Randomized Clinical Trial." @default.
• W2484812056 cites W1975870239 @default.
• W2484812056 cites W1980494785 @default.
• W2484812056 cites W1990944689 @default.
• W2484812056 cites W1998279172 @default.
• W2484812056 cites W2001458321 @default.
• W2484812056 cites W2001997032 @default.
• W2484812056 cites W2008133471 @default.
• W2484812056 cites W2017046927 @default.
• W2484812056 cites W2018912237 @default.
• W2484812056 cites W2022506684 @default.
• W2484812056 cites W2022803490 @default.
• W2484812056 cites W2024818417 @default.
• W2484812056 cites W2029896062 @default.
• W2484812056 cites W2034828629 @default.
• W2484812056 cites W2043537094 @default.
• W2484812056 cites W2044798205 @default.
• W2484812056 cites W2045434168 @default.
• W2484812056 cites W2046031762 @default.
• W2484812056 cites W2046093124 @default.
• W2484812056 cites W2052027047 @default.
• W2484812056 cites W2068676696 @default.
• W2484812056 cites W2072626594 @default.
• W2484812056 cites W2084000967 @default.
• W2484812056 cites W2087538363 @default.
• W2484812056 cites W2090310294 @default.
• W2484812056 cites W2096729555 @default.
• W2484812056 cites W2105984088 @default.
• W2484812056 cites W2115175546 @default.
• W2484812056 cites W2124737300 @default.
• W2484812056 cites W2124970404 @default.
• W2484812056 cites W2128406097 @default.
• W2484812056 cites W2131099228 @default.
• W2484812056 cites W2133416691 @default.
• W2484812056 cites W2144385879 @default.
• W2484812056 cites W2145739374 @default.
• W2484812056 cites W2151244707 @default.
• W2484812056 cites W2151837102 @default.
• W2484812056 cites W2152292563 @default.
• W2484812056 cites W2153109891 @default.
• W2484812056 cites W2156852140 @default.
• W2484812056 cites W2162017792 @default.
• W2484812056 cites W2601578636 @default.
• W2484812056 doi "https://doi.org/10.1001/jamapsychiatry.2016.1572" @default.
• W2484812056 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5267166" @default.
• W2484812056 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27487479" @default.
• W2484812056 hasPublicationYear "2016" @default.
• W2484812056 type Work @default.
• W2484812056 sameAs 2484812056 @default.
• W2484812056 citedByCount "49" @default.
• W2484812056 countsByYear W24848120562017 @default.
• W2484812056 countsByYear W24848120562018 @default.
• W2484812056 countsByYear W24848120562019 @default.
• W2484812056 countsByYear W24848120562020 @default.
• W2484812056 countsByYear W24848120562021 @default.
• W2484812056 countsByYear W24848120562022 @default.
• W2484812056 countsByYear W24848120562023 @default.
• W2484812056 crossrefType "journal-article" @default.
• W2484812056 hasAuthorship W2484812056A5000061600 @default.
• W2484812056 hasAuthorship W2484812056A5000501122 @default.
• W2484812056 hasAuthorship W2484812056A5004468255 @default.
• W2484812056 hasAuthorship W2484812056A5010718326 @default.
• W2484812056 hasAuthorship W2484812056A5012854700 @default.
• W2484812056 hasAuthorship W2484812056A5016425494 @default.
• W2484812056 hasAuthorship W2484812056A5019104236 @default.
• W2484812056 hasAuthorship W2484812056A5021284732 @default.
• W2484812056 hasAuthorship W2484812056A5026207242 @default.
• W2484812056 hasAuthorship W2484812056A5040266732 @default.
• W2484812056 hasAuthorship W2484812056A5042337330 @default.
• W2484812056 hasAuthorship W2484812056A5046908675 @default.
• W2484812056 hasAuthorship W2484812056A5051056050 @default.
• W2484812056 hasAuthorship W2484812056A5052901925 @default.
• W2484812056 hasAuthorship W2484812056A5053874473 @default.
• W2484812056 hasAuthorship W2484812056A5068855118 @default.
• W2484812056 hasAuthorship W2484812056A5077534388 @default.
• W2484812056 hasAuthorship W2484812056A5085153302 @default.

• next