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- W2484980188 abstract "The notion that the genetic material is a stable and invariable entity has long held sway over scientific thinking. Evidence has accumulated in recent years, however, that both prokaryotic and eukaryotic genomes are more dynamic and labile than previously believed. Genetic lability is now being seen as providing a basis for the generation of diversity in a variety of biological systems, e.g. differentiation, expression of the histocompatibility locus and genes coding for surface antigens, immunoglobulins, etc. The thesis that genetic instability and the consequence of it in the expression of genes could be the cause of malignant transformation has now attracted many adherents. Fidler and Kripke (1977) showed that diversity is being constantly generated in cancers. In this chapter and in Chapter 7, this thesis is extended to the generation of metastatic pheno-types and metastatic diversity in primary tumours and evidence will be reviewed which shows not only the innate genetic instability of cancers but also how it might be involved in the generation of variants with new phenotypes." @default.
- W2484980188 created "2016-08-23" @default.
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- W2484980188 date "1987-01-01" @default.
- W2484980188 modified "2023-09-23" @default.
- W2484980188 title "The Genetic Instability of Neoplasms" @default.
- W2484980188 doi "https://doi.org/10.1007/978-1-349-09577-3_6" @default.
- W2484980188 hasPublicationYear "1987" @default.
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