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- W2485014716 abstract "Publisher Summary This chapter focuses on the mammalian nervous system. It is recognized that similar mechanisms may occur in other organisms and many important aspects of apoptosis are discovered during the studies of nematode Caenorhabditis elegans. Biochemical events that define apoptosis include upregulation and/or mitochondrial translocation of proapoptotic proteins, such as Bax and Par-4; formation of mitochondrial permeability transition pores and the release of cytochrome c and/or apoptosis-inducing factor (AIF) from the mitochondria; activation of effector caspases that control the cell death process by cleaving a range of cytoplasmic, membrane-associated and nuclear protein substrates; exposure of phosphatidylserine on the plasma membrane surface that serves as a signal for recognition; and engulfment of the dying cell by macrophages and microglia. During embryonic and early postnatal development, many cells undergo apoptosis in most regions of mammalian nervous systems. Such developmental apoptosis is believed to be adaptive in that it eliminates cells that are not integrated into neuronal circuits and are therefore, unnecessary for the proper function of the nervous system." @default.
- W2485014716 created "2016-08-23" @default.
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- W2485014716 date "2012-01-01" @default.
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- W2485014716 title "Apoptosis and Necrosis" @default.
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