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• W2485034626 abstract "The buccal mucosa is attracting increasing interest as a site of administration forsystemic delivery of drugs because the acidic and enzyme-rich gastrointestinal (GI)milieu is bypassed and hepatic first-pass metabolism is avoided (Ho et al., 1992;Merkle and Wolany, 1992). However, an important limitation to delivery via thebuccal route is that the epithelium constitutes a physical barrier to the permeability of hydrophilic, as well as some lipophilic drugs, and it also represents abiochemical barrier to enzyme labile drugs. To evaluate potential drug substancesfor buccal drug delivery it is necessary that both in vivo and in vitro studies are conducted. The permeability of the drug across the epithelium should be investigatedin vitro along with studies of, e.g. metabolism and toxicity. For that purpose, validin vitro models of the human buccal epithelium are required. In recent decadesseveral different models have been used, most of which involves the use of experimental animals. The human TR146 cell culture model has been set up in ourlaboratory and is currently being used as an in vitro model for, e.g. permeabilitystudies with human buccal epithelium. The TR146 cell culture model has beencharacterized and compared with excised buccal mucosa from man and pig by theuse of Ussing chambers. In this chapter, an introduction to the barrier propertiesof buccal mucosa is given. In addition, the TR146 cell culture model and theporcine in vitro model are described and their applications are compared anddiscussed." @default.
• W2485034626 created "2016-08-23" @default.
• W2485034626 creator A5075485219 @default.
• W2485034626 date "2002-08-08" @default.
• W2485034626 modified "2023-10-05" @default.
• W2485034626 title "In vitro models of the human buccal epithelium: the TR146 cell culture model and the porcine in vitro model" @default.
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• W2485034626 doi "https://doi.org/10.1201/9780203219935-26" @default.
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