FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2485067797> ?p ?o ?g. }

• W2485067797 endingPage "336" @default.
• W2485067797 startingPage "330" @default.
• W2485067797 abstract "Objective: This work was undertaken to develop colon targeted tablets that can minimize premature release of ibuprofen (IBP) and metronidazole (MNZ) in a lag period of 7h during which the tablets are likely to remain in the upper gastro-intestinal tract, and produce rapid pulse release within 1-5 h after the lag period when the tablets could be located in the colon with or without intervention of colonic microflora. Methods: Core tablets of ibuprofen and metronidazole containing different amounts of tri-sodium citrate (TSC) as osmogen were compression coated with locust bean gum (LBG) and carboxymethyl LBG (CMLBG). In vitro drug release studies were performed in a dynamic pH shift condition with or without rat cecal matters. The release of the drugs were also monitored at different hydrodynamic conditions. Results: In vitro release studies revealed that increase in the amount of TSC, decrease in coat-weight and change in hydrodynamic conditions influenced the drug release considerably. While LBG coated tablets under the stated conditions failed to provide complete release of the drugs in 12 h, CMLBG coated tablets produced complete release rapidly in the post lag period minimizing the release in the initial 7 h. Presence of rat cecal matter in dissolution medium further accentuated the release of the drugs from CMLBG compression coated tablets in the post lag period. Conclusion: The study revealed that tablets containing appropriate amount of osmogen in the core and compression coated with suitable amount of CMLBG may be suitable for colon targeting of drugs even in the absence of colonic microflora." @default.
• W2485067797 created "2016-08-23" @default.
• W2485067797 creator A5003003310 @default.
• W2485067797 creator A5040159124 @default.
• W2485067797 creator A5055045412 @default.
• W2485067797 date "2016-06-01" @default.
• W2485067797 modified "2023-09-25" @default.
• W2485067797 title "FACTORS INFLUENCING DELAYED RELEASE FOLLOWED BY RAPID PULSE RELEASE OF DRUGS FROM COMPRESSION COATED TABLETS FOR COLON TARGETING" @default.
• W2485067797 cites W1148581362 @default.
• W2485067797 cites W1969289712 @default.
• W2485067797 cites W1980715469 @default.
• W2485067797 cites W1984056224 @default.
• W2485067797 cites W1989290224 @default.
• W2485067797 cites W1995464122 @default.
• W2485067797 cites W1998009139 @default.
• W2485067797 cites W1999028926 @default.
• W2485067797 cites W1999608432 @default.
• W2485067797 cites W2005044963 @default.
• W2485067797 cites W2007674178 @default.
• W2485067797 cites W2007807223 @default.
• W2485067797 cites W2009345062 @default.
• W2485067797 cites W2010721839 @default.
• W2485067797 cites W2044109296 @default.
• W2485067797 cites W2049883735 @default.
• W2485067797 cites W2068686072 @default.
• W2485067797 cites W2069417660 @default.
• W2485067797 cites W2089708288 @default.
• W2485067797 cites W2098254778 @default.
• W2485067797 cites W2122623396 @default.
• W2485067797 cites W2131698002 @default.
• W2485067797 cites W2137709802 @default.
• W2485067797 cites W2172033163 @default.
• W2485067797 cites W2173745151 @default.
• W2485067797 cites W2188841824 @default.
• W2485067797 cites W2279474934 @default.
• W2485067797 cites W2905907935 @default.
• W2485067797 cites W386204717 @default.
• W2485067797 cites W3103209045 @default.
• W2485067797 hasPublicationYear "2016" @default.
• W2485067797 type Work @default.
• W2485067797 sameAs 2485067797 @default.
• W2485067797 citedByCount "0" @default.
• W2485067797 crossrefType "journal-article" @default.
• W2485067797 hasAuthorship W2485067797A5003003310 @default.
• W2485067797 hasAuthorship W2485067797A5040159124 @default.
• W2485067797 hasAuthorship W2485067797A5055045412 @default.
• W2485067797 hasConcept C159985019 @default.
• W2485067797 hasConcept C185592680 @default.
• W2485067797 hasConcept C186060115 @default.
• W2485067797 hasConcept C192562407 @default.
• W2485067797 hasConcept C200990466 @default.
• W2485067797 hasConcept C2777396551 @default.
• W2485067797 hasConcept C2779335760 @default.
• W2485067797 hasConcept C2779944601 @default.
• W2485067797 hasConcept C2780035454 @default.
• W2485067797 hasConcept C2780100132 @default.
• W2485067797 hasConcept C2993377847 @default.
• W2485067797 hasConcept C43617362 @default.
• W2485067797 hasConcept C501593827 @default.
• W2485067797 hasConcept C55493867 @default.
• W2485067797 hasConcept C71924100 @default.
• W2485067797 hasConcept C86803240 @default.
• W2485067797 hasConcept C98274493 @default.
• W2485067797 hasConceptScore W2485067797C159985019 @default.
• W2485067797 hasConceptScore W2485067797C185592680 @default.
• W2485067797 hasConceptScore W2485067797C186060115 @default.
• W2485067797 hasConceptScore W2485067797C192562407 @default.
• W2485067797 hasConceptScore W2485067797C200990466 @default.
• W2485067797 hasConceptScore W2485067797C2777396551 @default.
• W2485067797 hasConceptScore W2485067797C2779335760 @default.
• W2485067797 hasConceptScore W2485067797C2779944601 @default.
• W2485067797 hasConceptScore W2485067797C2780035454 @default.
• W2485067797 hasConceptScore W2485067797C2780100132 @default.
• W2485067797 hasConceptScore W2485067797C2993377847 @default.
• W2485067797 hasConceptScore W2485067797C43617362 @default.
• W2485067797 hasConceptScore W2485067797C501593827 @default.
• W2485067797 hasConceptScore W2485067797C55493867 @default.
• W2485067797 hasConceptScore W2485067797C71924100 @default.
• W2485067797 hasConceptScore W2485067797C86803240 @default.
• W2485067797 hasConceptScore W2485067797C98274493 @default.
• W2485067797 hasIssue "8" @default.
• W2485067797 hasLocation W24850677971 @default.
• W2485067797 hasOpenAccess W2485067797 @default.
• W2485067797 hasPrimaryLocation W24850677971 @default.
• W2485067797 hasRelatedWork W1148581362 @default.
• W2485067797 hasRelatedWork W1665232424 @default.
• W2485067797 hasRelatedWork W2076057642 @default.
• W2485067797 hasRelatedWork W2116965399 @default.
• W2485067797 hasRelatedWork W2121694251 @default.
• W2485067797 hasRelatedWork W2126945720 @default.
• W2485067797 hasRelatedWork W2127932268 @default.
• W2485067797 hasRelatedWork W2181653096 @default.
• W2485067797 hasRelatedWork W2183104916 @default.
• W2485067797 hasRelatedWork W2369130938 @default.
• W2485067797 hasRelatedWork W2391581698 @default.
• W2485067797 hasRelatedWork W2392987041 @default.
• W2485067797 hasRelatedWork W2519355459 @default.
• W2485067797 hasRelatedWork W2793962288 @default.

• next