Matches in SemOpenAlex for { <https://semopenalex.org/work/W2485199946> ?p ?o ?g. }
Showing items 1 to 93 of
93
with 100 items per page.
- W2485199946 endingPage "2012" @default.
- W2485199946 startingPage "2008" @default.
- W2485199946 abstract "<h3>Background</h3> Simeprevir plus sofosbuvir (SIM/SOF) regimen was recommended by professional guidelines for certain patients with HCV genotype 1 infection and there is lack of data about this regimen in patients with genotype 4 infection. <h3>Aim</h3> To evaluate the efficacy and safety of this regimen in Egyptian patients with chronic HCV genotype 4 infection in the real world. <h3>Methods</h3> Multicentre observational study included 583 patients with HCV genotype 4 infection who began 12 weeks of treatment with SIM plus SOF. Demographic, clinical and virological data as well as adverse outcomes were collected. Treatment naïve patients were 342 (59%) of all included patients, 45% of patients had severe fibrosis (F3 and F4) while 55% had mild fibrosis (F1 and F2) and the primary outcome was sustained virological response (SVR). <h3>Results</h3> The overall SVR rate was 95.7% (558 out of 583 patients). In total, SVR12 in naïve patients with mild fibrosis score (F1 and F2) was achieved in 98.9% (94/95) for F1 and 98.1% (105/107) for F2, while naïve patients with severe fibrosis (F3 and F4) achieved SVR of 97.7% (86/88) for F3 and (42/52) 80.8% for F4. SVR in patients with previous interferon treatment achieved in 100% (45/45) for patients with F1 and 98.7% (74/75) for F2. While 94.7% (72/76) in experienced patients with F3; and 88.9% (40/45) for F4 achieved SVR12. Notable side effects included rash in 21 patients, photosensitivity in 18 patients, pruritus in 44 patients and hyperbilirubinemia in 42 patients. <h3>Conclusions</h3> A 12-week regimen of simeprevir/sofosbuvir was efficacious and well tolerated by treatment-naïve and treatment-experienced patients with chronic HCV genotype 4." @default.
- W2485199946 created "2016-08-23" @default.
- W2485199946 creator A5006603271 @default.
- W2485199946 creator A5023790424 @default.
- W2485199946 creator A5026072524 @default.
- W2485199946 creator A5068774709 @default.
- W2485199946 creator A5080428947 @default.
- W2485199946 date "2016-08-10" @default.
- W2485199946 modified "2023-10-16" @default.
- W2485199946 title "Efficacy and safety of sofosbuvir plus simeprevir therapy in Egyptian patients with chronic hepatitis C: a real-world experience" @default.
- W2485199946 cites W1969720994 @default.
- W2485199946 cites W1974027259 @default.
- W2485199946 cites W1977300462 @default.
- W2485199946 cites W2008646009 @default.
- W2485199946 cites W2016703647 @default.
- W2485199946 cites W2045597627 @default.
- W2485199946 cites W2053655447 @default.
- W2485199946 cites W2138619940 @default.
- W2485199946 cites W2143244227 @default.
- W2485199946 cites W2151554611 @default.
- W2485199946 cites W2164466220 @default.
- W2485199946 cites W2209281674 @default.
- W2485199946 cites W2287448501 @default.
- W2485199946 cites W2290229326 @default.
- W2485199946 cites W2292066952 @default.
- W2485199946 doi "https://doi.org/10.1136/gutjnl-2016-312012" @default.
- W2485199946 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27511197" @default.
- W2485199946 hasPublicationYear "2016" @default.
- W2485199946 type Work @default.
- W2485199946 sameAs 2485199946 @default.
- W2485199946 citedByCount "28" @default.
- W2485199946 countsByYear W24851999462016 @default.
- W2485199946 countsByYear W24851999462017 @default.
- W2485199946 countsByYear W24851999462018 @default.
- W2485199946 countsByYear W24851999462019 @default.
- W2485199946 countsByYear W24851999462020 @default.
- W2485199946 countsByYear W24851999462021 @default.
- W2485199946 crossrefType "journal-article" @default.
- W2485199946 hasAuthorship W2485199946A5006603271 @default.
- W2485199946 hasAuthorship W2485199946A5023790424 @default.
- W2485199946 hasAuthorship W2485199946A5026072524 @default.
- W2485199946 hasAuthorship W2485199946A5068774709 @default.
- W2485199946 hasAuthorship W2485199946A5080428947 @default.
- W2485199946 hasConcept C126322002 @default.
- W2485199946 hasConcept C141071460 @default.
- W2485199946 hasConcept C197934379 @default.
- W2485199946 hasConcept C203014093 @default.
- W2485199946 hasConcept C2522874641 @default.
- W2485199946 hasConcept C2776455275 @default.
- W2485199946 hasConcept C2778390639 @default.
- W2485199946 hasConcept C2778570526 @default.
- W2485199946 hasConcept C2778986448 @default.
- W2485199946 hasConcept C2780040827 @default.
- W2485199946 hasConcept C2781413609 @default.
- W2485199946 hasConcept C3020491458 @default.
- W2485199946 hasConcept C71924100 @default.
- W2485199946 hasConcept C90924648 @default.
- W2485199946 hasConceptScore W2485199946C126322002 @default.
- W2485199946 hasConceptScore W2485199946C141071460 @default.
- W2485199946 hasConceptScore W2485199946C197934379 @default.
- W2485199946 hasConceptScore W2485199946C203014093 @default.
- W2485199946 hasConceptScore W2485199946C2522874641 @default.
- W2485199946 hasConceptScore W2485199946C2776455275 @default.
- W2485199946 hasConceptScore W2485199946C2778390639 @default.
- W2485199946 hasConceptScore W2485199946C2778570526 @default.
- W2485199946 hasConceptScore W2485199946C2778986448 @default.
- W2485199946 hasConceptScore W2485199946C2780040827 @default.
- W2485199946 hasConceptScore W2485199946C2781413609 @default.
- W2485199946 hasConceptScore W2485199946C3020491458 @default.
- W2485199946 hasConceptScore W2485199946C71924100 @default.
- W2485199946 hasConceptScore W2485199946C90924648 @default.
- W2485199946 hasIssue "11" @default.
- W2485199946 hasLocation W24851999461 @default.
- W2485199946 hasLocation W24851999462 @default.
- W2485199946 hasOpenAccess W2485199946 @default.
- W2485199946 hasPrimaryLocation W24851999461 @default.
- W2485199946 hasRelatedWork W2019722329 @default.
- W2485199946 hasRelatedWork W2022555003 @default.
- W2485199946 hasRelatedWork W2114705120 @default.
- W2485199946 hasRelatedWork W2325419293 @default.
- W2485199946 hasRelatedWork W2521057748 @default.
- W2485199946 hasRelatedWork W2542141975 @default.
- W2485199946 hasRelatedWork W2565767304 @default.
- W2485199946 hasRelatedWork W2598210959 @default.
- W2485199946 hasRelatedWork W4245914075 @default.
- W2485199946 hasRelatedWork W4300554038 @default.
- W2485199946 hasVolume "66" @default.
- W2485199946 isParatext "false" @default.
- W2485199946 isRetracted "false" @default.
- W2485199946 magId "2485199946" @default.
- W2485199946 workType "article" @default.